3-methylmalate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

187 compounds within 3 steps: 2 in 1, 32 in 2, 153 in 3

One step

glyoxylateReach from here →
1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by CLYBL
propanoyl-CoAReach from here →
1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by CLYBL

Two steps

N-octanoyl-(2S)-hydroxyglycineReach from here →
1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
2. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
Catalysed by CLYBL, PAM
N-decanoyl-(2S)-hydroxyglycineReach from here →
1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
2. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
Catalysed by CLYBL, PAM
N-dodecanoyl-(2S)-hydroxyglycineReach from here →

Three steps

propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

Catalysed by CLYBL, PAM

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by CLYBL, PAM

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

Catalysed by CLYBL, PAM

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

Catalysed by CLYBL, PAM

pyruvateReach from here →

Catalysed by CLYBL, AGXT, AGXT2

(S)-malateReach from here →

Catalysed by CLYBL

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by CLYBL, AADAT

2-oxobutanoateReach from here →

Catalysed by CLYBL, AGXT2

propanoyl-4'-phosphopantetheineReach from here →

Catalysed by CLYBL, NUDT19, NUDT7, NUDT8

propanoateReach from here →

Catalysed by CLYBL, ACOT8, ACAA2, ACOT9

indole-3-pyruvateReach from here →

Catalysed by CLYBL, AADAT

4-methyl-2-oxopentanoateReach from here →

Catalysed by CLYBL, AADAT

3-phenylpyruvateReach from here →

Catalysed by CLYBL, AADAT

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by CLYBL, AGXT2

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by CLYBL, AGXT2

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by CLYBL, AGXT2

glycolateReach from here →

Catalysed by CLYBL, GRHPR

oxalateReach from here →

Catalysed by CLYBL, HAO1

3-(4-hydroxyphenyl)pyruvateReach from here →

Catalysed by CLYBL, AADAT

O-propanoyl-(R)-carnitineReach from here →

Catalysed by CLYBL, CRAT

glycineReach from here →

Catalysed by CLYBL, AADATOne of 15 routes

(S)-methylmalonyl-CoAReach from here →

Catalysed by CLYBL, PCCA, PCCB

2-methyl-3-oxobutanoyl-CoAReach from here →

Catalysed by CLYBL, ACAT1

acryloyl-CoAReach from here →

Catalysed by CLYBL, ACAD8

2-oxoadipateReach from here →

Catalysed by CLYBL, AADAT

kynurenateReach from here →

Catalysed by CLYBL, KYAT3, AADAT

5-amino-2-oxopentanoateReach from here →

Catalysed by CLYBL, AGXT2

(4R)-4-hydroxy-2-oxoglutarateReach from here →

Catalysed by CLYBL, HOGA1

xanthurenateReach from here →

Catalysed by CLYBL, KYAT3, AADAT

(4S)-4-hydroxy-2-oxoglutarateReach from here →

Catalysed by CLYBL, HOGA1

, AADAT

, BAAT

peroxisome

One of 29 routes

2-hydroxybutyric acidReach from here →

Catalysed by CLYBL, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 3 routes

N(omega)-methyl-L-arginineReach from here →

Catalysed by CLYBL, AADAT, AGXT2One of 3 routes

(9Z)-octadecenamideReach from here →

Catalysed by CLYBL, PAM

glycoursodeoxycholateReach from here →

Catalysed by CLYBL, AADATcytosolOne of 2 routes

N-(9Z-octadecenoyl)glycineReach from here →

Catalysed by CLYBL, AADAT, GLYATL3, GLYATL2One of 2 routes

N-octadecanoylglycineReach from here →

Catalysed by CLYBL, AADAT, GLYATL2

N-(9Z-hexadecenoyl)-glycineReach from here →

Catalysed by CLYBL, AADAT, GLYATL2

acetoacetateReach from here →

Catalysed by CLYBL, AGXT, AGXT2mitochondrial matrix, cytosolOne of 4 routes

tetradecamideReach from here →

Catalysed by CLYBL, PAM

N(2)-(1-hydroxy-2-oxoethyl)-dGTPReach from here →

Catalysed by CLYBL, GRHPR, PARK7

N(2)-(1-hydroxy-2-oxoethyl)-GMPReach from here →

Catalysed by CLYBL, GRHPR, PARK7

N-hexadecanoylglycineReach from here →

Catalysed by CLYBL, AADAT, GLYATL3

N-dodecanoylglycineReach from here →

Catalysed by CLYBL, AADAT, GLYATL2One of 2 routes

N-(9Z,12Z,15Z)-octadecatrienoylglycineReach from here →

Catalysed by CLYBL, PAM