potassium atom

Three steps

• CHEBI:16633Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, MARS1extracellular space, cytosol

• CHEBI:16668Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrix

• quinolinic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Quinolinic Acid

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC22A6extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC12A2, SLC12A1, SLC6A14, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SDS and 1 moreextracellular space, cytosol

• tryptamineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, KYAT1extracellular space, cytosolOne of 3 routes

• melatoninReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

  Catalysed by SLC6A4, AANAT, ASMTextracellular space, cytosol

• glyoxylic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC12A2, SLC12A1, GAMTextracellular space, cytosolOne of 2 routes

• bilirubin IXalphaReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of bilirubin (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, SLC16A4 and 3 moreextracellular space, cytosolOne of 2 routes

• taurolithocholateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by SLC12A2, SLC12A1, SLC6A6, BAATextracellular space, cytosolOne of 6 routes

• CHEBI:17208Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosol

• homocysteineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosol

• anilineReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol, mitochondrial matrix

• CHEBI:17312Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• linoleic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• sulfiteReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:17380Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Proline by the Apical Imino Amino Acid Transporters
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC12A2, SLC12A1, CLTRN, SLC6A20 and 1 moreextracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CPT2 and 1 moreextracellular space, cytosol, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A6, MTO1extracellular space, cytosolOne of 6 routes

• 5-aminolevulinic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 3 moreextracellular space, cytosol, mitochondrial matrix

• diiodineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLC12A2, SLC12A1, SLC26A4, TPOextracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IL4I1extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC12A2, SLC12A1, SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A12, BHMT and 1 moreextracellular space, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, AARS1extracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, HALextracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 2 routes

• 3-oxopropanoic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A6, SLC6A14 and 1 moreextracellular space, cytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC12A2, SLC12A1, SLC6A14, GOT2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 8 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC12A2, SLC12A1, SLC5A7, CHKA and 1 moreextracellular space, cytosol

• seleniteReach from here →
  1. transport of Ca2+ and K+ (cytosol to extracellular)
  2. Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)
  3. selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)

  Catalysed by SLC24A1, SLC24A5, SLC24A4, SLC24A3 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes