CHEBI:18095

Three steps

• CHEBI:27540Reach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC1A4, ACSM4, ACSM1, ACSM2A and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• CHEBI:27760Reach from here →
  1. Transport of Hydroxy-Proline
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SLC1A4, SCLY, CTHextracellular space, cytosol

• elaidic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by CLTRN, SLC6A20, SLC6A14, TPH1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC1A4, ACAA1, SCP2, MYO5Bextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• 3-disulfanyl-L-alanineReach from here →
  1. Transport of Hydroxy-Proline
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC1A4, SLC7A9, SLC3A1, CTHextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CLTRN, SLC6A20, SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A35 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Ca(2+)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC12A2, SLC12A1 and 5 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, FARSB and 1 moreextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC1A4, AGXT2, DARS1extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and citrulline (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC1A4, SLC7A6, LACC1extracellular space, cytosol

• hypoioditeReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by CLTRN, SLC6A20, SLC26A4, MPO and 1 moreextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, NARS1extracellular space, cytosol

• hydrogenselenideReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by SLC1A4, MOCOS, SCLYextracellular space, cytosol

• phosphocholineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by CLTRN, SLC6A20, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CLTRN, SLC6A20, SLC6A14, CTHextracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC26A4, SLC16A4 and 2 moreextracellular space, cytosolOne of 4 routes

• CHEBI:30249Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by CLTRN, SLC6A20, SLC6A14, IDO1 and 2 moreextracellular space, cytosol

• oxalateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• anthranilic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. L-Kynurenine hydrolase

  Catalysed by SLC1A4, KYNUextracellular space, cytosol

• propionic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC26A4, SLC16A4 and 2 moreextracellular space, cytosolOne of 4 routes

• citric acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• butyric acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC26A4, SLC16A4 and 1 moreextracellular space, cytosolOne of 4 routes

• maleateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• orotateReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 1 morecytosol

• 3-hydroxypyruvic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC1A4, AGXT2, AGXTextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• isocitric acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (2R,3R)-tartrateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• L-lysineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC7A9 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-lysineReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC1A4, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC1A4, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• N-carbamoyl-L-aspartateReach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC1A4, AGXT2, CADextracellular space, cytosol