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Reach

dTDP

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

215 compounds within 3 steps: 5 in 1, 51 in 2, 159 in 3

Does it reach a compound?

Two steps

(3S)-citramalyl-CoAReach from here →
1. pyruvate kinase (dTDP)
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by PKM, PKLR, CLYBLcytosol
5-amino-2-oxopentanoateReach from here →
1. pyruvate kinase (dTDP)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by PKM, PKLR, AGXT2cytosol
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. pyruvate kinase (dTDP)
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by PKM, PKLR, HOGA1cytosol
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. pyruvate kinase (dTDP)
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by PKM, PKLR, HOGA1cytosol
thiamine(1+) diphosphateReach from here →
1. deoxythymidylate kinase (dADP)
2. Antiport of thiamine-diphosphate and dATP
Catalysed by DTYMK, SLC25A19mitochondrial matrix, cytosolOne of 2 routes
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. pyruvate kinase (dTDP)
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by PKM, PKLR, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by PKM, PKLR, ADHFE1cytosol, mitochondrial matrix
CHEBI:1146900Reach from here →
Catalysed by DTYMK and 1 more

Page 2 of 5

, HK1

, HK2

, HKDC1

mitochondrial matrix, cytosol

One of 5 routes

N(omega)-methyl-L-arginineReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by PKM, PKLR, AGXT2cytosol, mitochondrial matrixOne of 3 routes

3-hydroxy-2-methylpropanoateReach from here →

pyruvate kinase (dTDP)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

Catalysed by PKM, PKLR, AGXT2, HIBADHcytosol

prostaglandin E3Reach from here →

pyruvate kinase (dTDP)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin E3, Lactate Antiport

Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

prostaglandin A2Reach from here →

pyruvate kinase (dTDP)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin A2, Lactate Antiport

Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

pyruvate kinase (dTDP)
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

pyruvate kinase (dTDP)
(S)-Lactate:NAD+ oxidoreductase
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

pyruvate kinase (dTDP)
transport of pyruvate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

pyruvate kinase (dTDP)
transport of acetate and pyruvate (cytosol to extracellular)
N-acetylcadaverine + H2O = cadaverine + acetate

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

pyruvate kinase (dTDP)
transport of pyruvate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 7 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

pyruvate kinase (dTDP)
transport of pyruvate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 29 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

pyruvate kinase (dTDP)
transport of acetate and pyruvate (cytosol to extracellular)
a phenyl acetate + H2O = a phenol + acetate + H(+)

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

CHEBI:15345Reach from here →

pyruvate kinase (dTDP)
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by PKM, PKLR, AACScytosol, mitochondrial matrixOne of 3 routes

acetoneReach from here →

pyruvate kinase (dTDP)
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate carboxy-lyase (acetone-forming)

Catalysed by PKM, PKLRcytosol, mitochondrial matrix

propionyl-CoAReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)

Catalysed by PKM, PKLR, AGXT2, ALDH6A1cytosol, mitochondrial matrixOne of 5 routes

CHEBI:15570Reach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
alanine racemase

Catalysed by PKM, PKLR, AGXT2cytosol, mitochondrial matrix

L-leucineReach from here →

nucleoside-diphosphate kinase (dADP)
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
thioredoxin phosphorylation

Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrixOne of 12 routes

10-formyltetrahydrofolic acidReach from here →

pyruvate kinase (dTDP)
transport of formate and pyruvate (cytosol to extracellular)
Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

2'-deoxycytidineReach from here →

nucleoside-diphosphate kinase (dADP)
cytidine/uridine monophosphate kinase (dADP)
2'-deoxycytidine 5'-monophosphate phosphohydrolase

Catalysed by NME4, NME6, NME1, NME2 and 12 morecytosolOne of 7 routes

CHEBI:15699Reach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
transport of alanine and homoserine (cytosol to extracellular)

Catalysed by PKM, PKLR, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

malonateReach from here →

pyruvate kinase (dTDP)
(S)-malate + NAD(+) = pyruvate + CO2 + NADH
malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Catalysed by PKM, PKLR, ME2, SLC25A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:15971Reach from here →

nucleoside-diphosphate kinase (dADP)
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
thioredoxin phosphorylation

Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

sulfateReach from here →

pyruvate kinase (dTDP)
(S)-malate + NAD(+) = pyruvate + CO2 + NADH
transport of malate and sulfate (cytosol to mitochondria)

Catalysed by PKM, PKLR, ME2, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

L-cystineReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

Catalysed by PKM, PKLR, AGXT2, SLC7A9 and 1 morecytosol, mitochondrial matrix, extracellular space

(R)-3-aminoisobutyric acidReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
(S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

Catalysed by PKM, PKLR, AGXT2, ABATcytosol, mitochondrial matrixOne of 3 routes

CHEBI:16332Reach from here →

deoxythymidylate kinase (dADP)
dATP:D-fructose 6-phosphotransferase
D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase

Catalysed by DTYMK, HK1, HK2, HK3 and 4 moremitochondrial matrix, cytosol

L-citrullineReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
transport of alanine and citrulline (cytosol to extracellular)

Catalysed by PKM, PKLR, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

L-valineReach from here →

nucleoside-diphosphate kinase (dADP)
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
thioredoxin phosphorylation

Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrixOne of 11 routes

L-arginineReach from here →

nucleoside-diphosphate kinase (dADP)
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
mitothioredoxin phosphorylation

Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrixOne of 9 routes

CHEBI:16497Reach from here →

DTTP Nucleotidohydrolase
pyruvate kinase (dTDP)
dGTP:pyruvate 2-O-phosphotransferase

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 1 moreextracellular space, cytosolOne of 13 routes

protein polypeptide chainReach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
PROTEIN_BS

Catalysed by PKM, PKLR, AGXT2cytosol, mitochondrial matrixOne of 2 routes

N(2)-acetyl-L-ornithineReach from here →

pyruvate kinase (dTDP)
transport of acetate and pyruvate (cytosol to extracellular)
N2-Acetyl-L-ornithine amidohydrolase

Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

CHEBI:16633Reach from here →

pyruvate kinase (dTDP)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
L-selenocysteine selenide-lyase (L-alanine-forming)

Catalysed by PKM, PKLR, AGXT2, SCLYcytosol, mitochondrial matrix

Met-tRNA(Met)Reach from here →

pyruvate kinase (dTDP)
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
L-Methionine:tRNAMet ligase (AMP-forming)

Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

(R)-glycerateReach from here →

pyruvate kinase (dTDP)
L-Serine:pyruvate aminotransferase
D-glycerate:NADP+ 2-oxidoreductase

Catalysed by PKM, PKLR, AGXT, GRHPRcytosolOne of 4 routes

4-methylsulfanyl-2-oxobutanoateReach from here →

pyruvate kinase (dTDP)
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

N-[(S)-lactoyl]-L-phenylalanineReach from here →

pyruvate kinase (dTDP)
(S)-lactate + NAD(+) = pyruvate + NADH + H(+)
(S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

Catalysed by PKM, PKLR, LDHA, LDHB and 4 morecytosol

CHEBI:16857Reach from here →

nucleoside-diphosphate kinase (dADP)
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
thioredoxin phosphorylation

Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol, mitochondrial matrixOne of 9 routes

D-erythrose 4-phosphateReach from here →

deoxythymidylate kinase (dADP)
dATP:D-fructose 6-phosphotransferase
D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase

Catalysed by DTYMK, HK1, HK2, HK3 and 4 moremitochondrial matrix, cytosol

ferrocytochrome cReach from here →

pyruvate kinase (dTDP)
(S)-Lactate:NAD+ oxidoreductase
(S)-Lactate:ferricytochrome-c 2-oxidoreductase

Catalysed by PKM, PKLR, LDHB, LDHAL6B and 1 morecytosol, mitochondrial matrixOne of 2 routes

glycolaldehydeReach from here →

pyruvate kinase (dTDP)
L-Serine:pyruvate aminotransferase
hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

Catalysed by PKM, PKLR, AGXTcytosolOne of 2 routes

aldehydo-N-acetyl-D-mannosamineReach from here →

pyruvate kinase (dTDP)
N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by PKM, PKLR, NPLcytosolOne of 2 routes

2'-deoxyguanosineReach from here →

nucleoside-diphosphate kinase (dADP)
dADP to dATP conversion
2'-deoxyguanosine 5'-monophosphate phosphohydrolase

Catalysed by NME4, NME6, NME1, NME2 and 11 morecytosol, mitochondrial matrixOne of 5 routes