3,3'-diiodo-L-thyronine sulfate

Three steps

• androsteroneReach from here →
  1. Steryl-Sulfatase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by STSGolgi apparatus, cytosolOne of 3 routes

• L-cystineReach from here →
  1. Steryl-Sulfatase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. Steryl-Sulfatase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by STSGolgi apparatus, cytosolOne of 3 routes

• ubiquinonesReach from here →
  1. Steryl-Sulfatase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by STS, SLC25A10, SDHD, SDHB and 2 moreGolgi apparatus, mitochondrial matrix, cytosol

• L-valineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. (R)-malate + A = oxaloacetate + AH2

  Catalysed by STS, DIO3, D2HGDHGolgi apparatusOne of 12 routes

• L-arginineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. Steryl-Sulfatase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membrane, cytosol

• pregnenoloneReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by STSGolgi apparatus, cytosolOne of 4 routes

• formaldehydeReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by STS, DIO3, KDM1A, KDM1BGolgi apparatusOne of 3 routes

• 3-fumarylpyruvateReach from here →
  1. Steryl-Sulfatase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by STS, SLC25A10, FAHD1Golgi apparatus, mitochondrial matrix, cytosol

• CHEBI:16856Reach from here →
  1. Steryl-Sulfatase
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by STS, DIO1, DIO3, DIO2 and 2 moreGolgi apparatus, cytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. Steryl-Sulfatase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by STS, SLC25A14, SLC25A30, SUOXGolgi apparatus, inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• N-acetyl-L-aspartateReach from here →
  1. Steryl-Sulfatase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, NAT8LGolgi apparatus, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20Golgi apparatus, extracellular space, cytosolOne of 3 routes

• estroneReach from here →
  1. Steryl-Sulfatase
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by STSGolgi apparatus, cytosolOne of 3 routes

• propanoateReach from here →
  1. Steryl-Sulfatase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 4 routes

• all-trans-retinolReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by STS, DIO3, RETSATGolgi apparatus

• enol-oxaloacetateReach from here →
  1. Steryl-Sulfatase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAGolgi apparatus, mitochondrial matrix, cytosol

• AH2Reach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. A + NADH + H(+) = AH2 + NAD(+)

  Catalysed by STS, DIO3, AIFM1, PYROXD1Golgi apparatusOne of 19 routes

• L-cysteineReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by STS, DIO3, MOCOSGolgi apparatusOne of 3 routes

• diiodineReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by STS, DIO3, TPOGolgi apparatus, cytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. Steryl-Sulfatase
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. aryl sulfotransferase (PAPS)

  Catalysed by STS, DIO1, DIO3, DIO2 and 4 moreGolgi apparatus, cytosolOne of 2 routes

• glycine betaineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12Golgi apparatus, extracellular space, cytosolOne of 3 routes

• urateReach from here →
  1. Steryl-Sulfatase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosolOne of 2 routes

• butanoateReach from here →
  1. Steryl-Sulfatase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by STS, SLC22A9Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosol

• thiocyanateReach from here →
  1. Steryl-Sulfatase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 moreGolgi apparatus, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Steryl-Sulfatase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHGolgi apparatus, mitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14Golgi apparatus, extracellular space, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20Golgi apparatus, extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by STS, SLC26A6Golgi apparatus, extracellular space, cytosolOne of 2 routes

• hydrogen cyanideReach from here →
  1. Steryl-Sulfatase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, MPST and 1 moreGolgi apparatus, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. Steryl-Sulfatase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. Steryl-Sulfatase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-thyronineReach from here →
  1. Steryl-Sulfatase
  2. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by STS, DIO1, DIO3Golgi apparatus

• CHEBI:240943Reach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by STS, SLC26A6, SLC6A5Golgi apparatus, extracellular space, cytosolOne of 2 routes

• a quinolReach from here →
  1. Steryl-Sulfatase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAGolgi apparatus, mitochondrial matrix, cytosol

• hypochlorous acidReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by STS, SLC26A6, LPOGolgi apparatus, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC12A2, SLC12A1Golgi apparatus, extracellular space, cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. Steryl-Sulfatase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by STSGolgi apparatus, cytosolOne of 3 routes

• K(+)Reach from here →
  1. Steryl-Sulfatase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC1A7 and 4 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. Steryl-Sulfatase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by STS, SLC25A14, SLC25A30, DARS1Golgi apparatus, inner side of the membrane, outer side of the membrane, cytosol

• hypoioditeReach from here →
  1. Steryl-Sulfatase
  2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by STS, DIO3, MPO, LPOGolgi apparatus

• hydrogen sulfideReach from here →
  1. Steryl-Sulfatase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 moreGolgi apparatus, inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• formic acidReach from here →
  1. Steryl-Sulfatase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4Golgi apparatus, extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. Steryl-Sulfatase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by STS, SLC25A10, SLC25A1Golgi apparatus, mitochondrial matrix, cytosolOne of 10 routes