3,3',5-triiodo-L-thyronine sulfate

Three steps

• estroneReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• propanoateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 5'-deoxyadenosineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by DIO1, AIFM1, PYROXD1, CDK5RAP1One of 4 routes

• enol-oxaloacetateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by DIO1, RETSAT, LRATcytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA

  Catalysed by DIO1, RETSAT, DGAT1, PNPLA4 and 3 moreOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by DIO1, DIO2, SULT1A3, SULT1A4 and 1 morecytosol

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by DIO1, AIFM1, PYROXD1

• CHEBI:17724Reach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by DIO1, KDM1A, KDM1B, PDPR and 1 morecytosol

• glycine betaineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 7 routes

• urateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 6 routes

• all-trans-retinalReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol: NADP+ oxidoreductase

  Catalysed by DIO1, RETSAT, DHRS3, RDH10 and 4 morecytosolOne of 6 routes

• butanoateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes

• thiocyanateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHcytosol, mitochondrial matrix

• a diacylglycerolReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol

  Catalysed by DIO1, RETSAT, PNPLA4, PNPLA2

• L-glutamineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 7 routes

• CHEBI:18095Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by STS, SLC26A6cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, MPST and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by DIO1, D2HGDH, AGXT2

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by DIO1, KDM1A, KDM1Bcytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by DIO1, MTO1, DHFR, DHFR2cytosolOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by DIO1, MOCOS, CARS2

• 3-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3One of 2 routes

• 3-iodo-L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3One of 3 routes

• 3'-iodo-L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO2One of 3 routes

• L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3

• thyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3

• 3'-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO2One of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO2One of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3

• 3,3',5'-triiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by DIO1, AIFM1, PYROXD1, DIO3

• CHEBI:240943Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by STS, SLC26A6, SLC6A5cytosol, extracellular spaceOne of 2 routes

• a quinolReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• hypochlorous acidReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by STS, SLC26A6, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• N-acetyl-L-cysteineReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DIO1, MOCOS, NAGSmitochondrial matrix

• K(+)Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC1A7 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• Cys-tRNA(Cys)Reach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by DIO1, MOCOS, CARS1cytosol

• Asp-tRNA(Asp)Reach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by STS, SLC25A14, SLC25A30, DARS1cytosol, inner side of the membrane, outer side of the membrane

• hydrogenselenideReach from here →
  1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by DIO1, AIFM1, PYROXD1, SCLY

• hydrogen sulfideReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• formic acidReach from here →
  1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular spaceOne of 2 routes