N-acetyl-L-aspartate

Three steps

• CHEBI:15650Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ASPA, ACY3, NAT8L, ZDHHC11B and 31 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15699Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and homoserine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A5cytosol, extracellular spaceOne of 29 routes

• CHEBI:15727Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by ASPA, ACY3, GAD2, CARNS1cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ASPA, ACY3, NAT8L, SAT1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15765Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. solute carrier (L-dopa)

  Catalysed by ASPA, ACY3, SLC7A13, SLC3A2 and 1 morecytosol, inner side of the membrane, outer side of the membrane, extracellular space

• malonateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by ASPA, ACY3, AMDHD2, CEMP1cytosolOne of 2 routes

• N-acetyl-beta-D-glucosaminylamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by ASPA, ACY3, AGAcytosol

• thioredoxin dithiolReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by ASPA, ACY3, DARS1cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and histidine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A6cytosol, extracellular spaceOne of 18 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ASPA, ACY3, NAT8L, DGAT1 and 4 morecytosol, mitochondrial matrix

• (R)-3-aminoisobutyric acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ASPA, ACY3, AGXT2cytosol, mitochondrial matrix

• L-citrullineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by ASPA, ACY3, ASS1cytosolOne of 18 routes

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by ASPA, ACY3, CYP17A1, AKR1C1cytosol, endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ASPA, ACY3, CYP17A1cytosol, endoplasmic reticulumOne of 5 routes

• L-arginineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASPA, ACY3, ASS1, ASLcytosolOne of 36 routes

• CHEBI:16523Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. transport of D-serine and glutamine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC7A13, SLC3A2 and 1 morecytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• 2-phenylacetamideReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by ASPA, ACY3, SLC7A13, EPXcytosol, inner side of the membrane, outer side of the membrane

• CHEBI:16633Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ASPA, ACY3, AGXT2, SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by ASPA, ACY3, SLC7A13, MARS1cytosol, inner side of the membrane, outer side of the membrane

• (S)-lactateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 8 morecytosol, extracellular space

• CHEBI:16668Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by ASPA, ACY3, SLC25A12, SLC25A13 and 2 morecytosol, mitochondrial matrix

• quinolinic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Transport of Quinolinic Acid

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by ASPA, ACY3, SLC7A13, AADATcytosol, inner side of the membrane, outer side of the membrane

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by ASPA, ACY3, SLC7A13, CNDP2cytosol, inner side of the membrane, outer side of the membrane

• 2-oxobutanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 6 morecytosol, extracellular spaceOne of 2 routes

• tryptamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan decarboxy-lyase

  Catalysed by ASPA, ACY3, SLC7A13, DDCcytosol, inner side of the membrane, outer side of the membrane

• 2-oxoglutaramateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 5 routes

• 3-fumarylpyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• CHEBI:16857Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and threonine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• ferrocytochrome cReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space, mitochondrial matrix

• oxalic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membrane, extracellular space

• 3-hydroxypyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and isoleucine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• 4-methylumbelliferoneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by ASPA, ACY3, CES2, ESD and 1 morecytosol

• anilineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ASPA, ACY3, NAT8L, NAT2 and 1 morecytosol, mitochondrial matrix

• aceneuramateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• CHEBI:17312Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrixOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• sulfiteReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-aspartic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of aspartate (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC1A7, SLC1A3 and 3 morecytosol, extracellular space

• CHEBI:17380Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by ASPA, ACY3, SLC7A13, SLC7A5cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. Aspartate Intake by System Asct-1 Transporter
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by ASPA, ACY3, PRODH2cytosol, extracellular spaceOne of 2 routes

• AH2Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ASPA, ACY3, SLC7A13, CDKAL1cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-cysteineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A5cytosol, extracellular spaceOne of 50 routes

• indole-3-pyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by ASPA, ACY3, SLC7A13, IL4I1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Steryl-Sulfatase

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, HADHA and 2 morecytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ASPA, ACY3, AGXT2, AARS1cytosol