glyoxylic acid

Two steps

• CHEBI:15971Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• sulfateReach from here →
  1. Glyoxylate:oxygen oxidoreductase
  2. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by HAO1, SLC26A6peroxisome, extracellular space, cytosolOne of 5 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT, AGXT2mitochondrial matrix

• 11-cis-retinolReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CLYBL, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• L-citrullineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A9, SLC3A1 and 1 moremitochondrial matrix, extracellular space, cytosol

• L-valineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and valine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by AGXT, AGXT2, PCmitochondrial matrixOne of 9 routes

• L-arginineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC3A2, SLC7A10mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. PROTEIN_BS

  Catalysed by AGXT, AGXT2mitochondrial matrix, cytosol

• (S)-lactateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by AGXT, AGXT2, LDHA, LDHB and 3 moremitochondrial matrix

• 2-oxobutanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by AGXT, AGXT2mitochondrial matrix

• 2-oxoglutaramateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. L-Glutamine:pyruvate aminotransferase

  Catalysed by AGXT, AGXT2, KYAT1mitochondrial matrix, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by AGXT, AGXT2, FAHD1mitochondrial matrix

• CHEBI:16856Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by AGXT, AGXT2, GSSmitochondrial matrix, cytosol

• CHEBI:16857Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC3A2, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by AGXT, AGXT2mitochondrial matrix

• L-isoleucineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and proline (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A5, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• anilineReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CLYBL, NAT2, NAT1mitochondrial matrix, cytosol

• aceneuramateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by AGXT, AGXT2, NPLmitochondrial matrix

• CHEBI:17312Reach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CLYBLmitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by AGXT, AGXT2, TYW1B, TYW1mitochondrial matrix

• sulfiteReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by CLYBL, SDHB, SDHAmitochondrial matrix

• 5-aminolevulinic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AGXT, AGXT2, ALAS1, ALAS2 and 1 moremitochondrial matrix

• L-cysteineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC3A2, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CLYBL, HADHA, ACADVL, HADHBmitochondrial matrix

• CHEBI:17895Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CLYBLmitochondrial matrix, cytosol

• fumaric acidReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by CLYBL, FHmitochondrial matrix, cytosolOne of 5 routes

• CHEBI:18019Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• dTDPReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. pyruvate kinase (dTDP)

  Catalysed by AGXT, AGXT2, PKM, PKLRmitochondrial matrix, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AGXT, AGXT2, GARTmitochondrial matrix, cytosol

• ophthalmateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by AGXT, AGXT2, GSSmitochondrial matrix

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT, AGXT2mitochondrial matrix

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT, AGXT2mitochondrial matrix

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT, AGXT2mitochondrial matrix

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT, AGXT2mitochondrial matrix

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by AGXT, AGXT2, SHMT1mitochondrial matrix, cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CLYBL, HADHA, ACAA2, HADHBmitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by CLYBL, HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by CLYBL, HADHA, ACADVL, HADHBmitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by CLYBL, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by CLYBL, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AGXT, AGXT2, GLYAT, GLYATL2 and 1 moremitochondrial matrix