CHEBI:16856

Three steps

• 17alpha-hydroxyprogesteroneReach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHE and 1 moreextracellular space, cytosol, endoplasmic reticulum

• anilineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 31 moreextracellular space, cytosol

• aceneuramateReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by CTH, NPLcytosol

• CHEBI:17312Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CTH, TYW1B, TYW1cytosol

• 3-hydroxy-3-methylglutarateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• all-trans-retinolReach from here →
  1. transport of GSH and thyroxine (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosol

• linoleic acidReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  No catalyst recordedextracellular space, cytosolOne of 14 routes

• D-aspartic acidReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC1A7 and 4 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A5, PRODH2cytosol, extracellular spaceOne of 2 routes

• agmatineReach from here →
  1. cystine to cysteine conversion
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A6cytosol, extracellular space, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. Utilized Transport
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CPT2, CPT1Aextracellular space, cytosol, endoplasmic reticulum, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosolOne of 25 routes

• 5-aminolevulinic acidReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by LTC4S, ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• diiodineReach from here →
  1. transport of GSH and thyroxine (cytosol to extracellular)
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2 and 1 moreextracellular space, cytosolOne of 2 routes

• 3,4-dihydroxyphenylacetateReach from here →
  1. transport of dopamine and GSH (cytosol to extracellular)
  2. monoamine oxidase (dopamine)
  3. 3,4-dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, AOC2, AOC1 and 6 moreextracellular space, cytosolOne of 3 routes

• indole-3-pyruvateReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A5, IL4I1cytosol, extracellular spaceOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. transport of GSH and thyroxine (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. 3,3',5'-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 4 moreextracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. Steryl-Sulfatase

  Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosol, Golgi apparatusOne of 7 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 32 moreextracellular space, cytosol, mitochondrial matrix

• xanthineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. ascorbate to monodehydroascorbate conversion
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by XDHcytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• glycine betaineReach from here →
  1. cystine to cysteine conversion
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC6A12cytosol, extracellular spaceOne of 3 routes

• glycerolReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. fatty acid amide hydrolase (2-arachidonoylglycerol)
  3. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by FAAH, CES2, ABHD16A, EPHX1 and 7 moreextracellular space, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHE and 3 moreextracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of GSH and histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. L-histidine = trans-urocanate + NH4(+)

  Catalysed by SLCO1A2, SLCO1B3, HDC, HALextracellular space, cytosolOne of 2 routes

• methylarsonous acidReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosolOne of 2 routes

• 4-methyl-2-oxopentanoateReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A9, SLC3A1, BCAT2cytosol, extracellular space, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A5, GOT2, TATcytosol, extracellular space, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and thiosulfate (cytosol to mitochondria)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• thiocyanateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• 5-hydroxyisourateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. ascorbate to monodehydroascorbate conversion
  3. urate:oxygen oxidoreductase

  No catalyst recordedcytosol

• dTDPReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. pyruvate kinase (dTDP)

  Catalysed by CTH, PKM, PKLRcytosol

• CHEBI:18095Reach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 5 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. Utilized Transport
  3. solute carrier (L-carnitine)

  Catalysed by SLC25A20extracellular space, cytosol, endoplasmic reticulum, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. ATP:choline phosphotransferase

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHE and 2 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. cystine to cysteine conversion
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC6A14cytosol, extracellular spaceOne of 2 routes

• dodecanoateReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  No catalyst recordedextracellular space, cytosolOne of 12 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by LTC4S, GARTcytosol

• arsenic triglutathioneReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes

• 2-phenylethylamineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A5, DDCcytosol, extracellular space

• hydrogen cyanideReach from here →
  1. Sulfide:glutathione,quinone oxidoreductase
  2. Persulfide dioxygenase
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SQOR, ETHE1, MPST, TSTmitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, PFAScytosol, extracellular space

• (R)-metanephrineReach from here →
  1. transport of GSH and noradrenaline (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:catechol O-methyltransferase
  3. (R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1A2, SLCO1B3, COMT, LRTOMT and 1 moreextracellular space, cytosol

• ophthalmateReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by LTC4S, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A5, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 6 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes