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Proteins/UNIPROT:P07099
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)..
Function from UniProtKB (P07099), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
149 statements
149 statements · 7 reference databases · Subject: EPHX1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
50 reactions
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+waterMAM01051c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00945CC BY 4.0Reference data
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+waterMAM01208c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
5 names
Resolves to: EPHX1
MAM00279c+waterMAM00277c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00953CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+waterMAM00364c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00957CC BY 4.0Reference data
MAM00098c+waterMAM00386c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01002CC BY 4.0Reference data
MAM00098x+waterMAM00386x
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10peroxisome
Human-GEM MAR01003CC BY 4.0Reference data
MAM00098r+waterMAM00386r
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10endoplasmic reticulum
Human-GEM MAR01004CC BY 4.0Reference data
MAM00098c+waterMAM00388c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01006CC BY 4.0Reference data
MAM00098x+waterMAM00388x
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10peroxisome
Human-GEM MAR01007CC BY 4.0Reference data
MAM00098r+waterMAM00388r
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10endoplasmic reticulum
Human-GEM MAR01008CC BY 4.0Reference data
MAM01058c+waterMAM02396c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01020CC BY 4.0Reference data
MAM01058n+waterMAM02396n
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10nucleus
Human-GEM MAR01021CC BY 4.0Reference data