2-oxoglutaramate

Three steps

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by KYAT1, AADAT, AGXT2

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by KYAT1, AGXT2cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by KYAT1, AADAT, AGXT2

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by KYAT1, AADAT, AGXT2

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by KYAT1, SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by KYAT1, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by KYAT1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by KYAT1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by KYAT1, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by KYAT1, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by KYAT1, SLC7A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Peroxidase

  Catalysed by KYAT1, SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by KYAT1, SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by KYAT1, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by KYAT1, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by KYAT1, SLC7A5extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by KYAT1, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by KYAT1, SCLYcytosol

• N-acetyl-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by KYAT1, AADAT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by KYAT1, GOT2, TAT, FARSB and 1 moremitochondrial matrix, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by KYAT1, SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by KYAT1, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by KYAT1, SLC7A5, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by KYAT1, SLC7A5, IARS1extracellular space, cytosol

• isocyanateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of citrulline and glutamine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by KYAT1, SLC7A6, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by KYAT1, ASNS, NARS1cytosol

• glycocholateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by KYAT1, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glycolateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by KYAT1, AADAT, GRHPR

• hydrogen sulfideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by KYAT1, SLC7A5, IDO1, TDO2 and 1 moreextracellular space, cytosol

• oxalateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by KYAT1, AADAT, HAO1

• formic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Malonate Transport, Antiport with Chloride

  Catalysed by KYAT1, SLC6A14extracellular space, cytosolOne of 2 routes

• glutarateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by KYAT1, AADAT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-lysineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by KYAT1, SLC7A5, SLC7A7extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by KYAT1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by KYAT1, SLC7A6, SLC3A2, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by KYAT1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by KYAT1, CADcytosolOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by KYAT1, SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 7 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by KYAT1, SLC7A5, BCAT2, BCAT1extracellular space, cytosol