CHEBI:16523

Three steps

• leukotriene F4Reach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, GSSextracellular space, cytosolOne of 4 routes

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by SLC3A2, SLC7A10, GSS, GSTA1 and 1 moreextracellular space, cytosol

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by SLC3A2, SLC7A10, GSS, GSTP1 and 1 moreextracellular space, cytosol

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC3A2, SLC7A10, GSS, GSTA1 and 2 moreextracellular space, cytosol

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by SLC3A2, SLC7A10, GSS, GSTP1 and 1 moreextracellular space, cytosol

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLC3A2, SLC7A10, BAAT, SLCO1A2 and 1 moreextracellular space, cytosol, peroxisomeOne of 11 routes

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC3A2, SLC7A10, SLC7A5, PM20D1extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC3A2, SLC7A10, SLC7A5, PM20D1extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC3A2, SLC7A10, SLC7A5, PM20D1extracellular space, cytosol

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by SLC3A2, SLC7A10, GSS, GSTM4 and 1 moreextracellular space, cytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazoleReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)
  3. 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)

  Catalysed by SLC3A2, SLC7A10, PFAS, GARTextracellular space, cytosol

• S-methyl glutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC3A2, SLC7A10, GSS, MMACHCextracellular space, cytosol

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by SLC3A2, SLC7A10, AADAT, PAMextracellular space, cytosol

• D-histidineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by SLC3A2, SLC7A10, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC3A2, SLC7A10, SLC7A6, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC3A2, SLC7A10, SLC7A6, CARNS1extracellular space, cytosol

• 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactoneReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
  3. D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + 2 H(+)

  Catalysed by SLC3A2, SLC7A10, GFPT2, GFPT1 and 1 moreextracellular space, cytosol

• 2,3-didehydrophenylalanineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC3A2, SLC7A10, DPEP1extracellular space, cytosol

• S-adenosylglutathioneReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC3A2, SLC7A10, GSS, MMACHCextracellular space, cytosol

• N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
  3. N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)

  Catalysed by SLC3A2, SLC7A10, GARTextracellular space, cytosol

• kinetensinReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by SLC3A2, SLC7A10, SLC7A5, CMA1extracellular space, cytosolOne of 3 routes

• (7Z)-octadecenoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SLC3A2, SLC7A10, CPT1A, CPT1C and 1 moreextracellular space, cytosolOne of 3 routes

• acetaldehydeReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC3A2, SLC7A10, SLC7A5extracellular space, cytosolOne of 2 routes

• CHEBI:15345Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, AACSextracellular space, cytosolOne of 2 routes

• cholineReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, SLC6A14, SLC5A7extracellular space, cytosolOne of 2 routes

• acetylcholineReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• pyruvateReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC3A2, SLC7A10, KYAT1, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 21 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SLC3A2, SLC7A10, SLC7A5, TPH1 and 1 moreextracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SLC3A2, SLC7A10, ALAS1, CPNE7extracellular space, cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC3A2, SLC7A10, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC3A2, SLC7A10, CPT1A, CPT1Bextracellular space, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC3A2, SLC7A10, HADHA, ACAA2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC3A2, SLC7A10, GLYATextracellular space, cytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC3A2, SLC7A10, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, SLC27A2, ACSL4 and 6 moreextracellular space, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SLC3A2, SLC7A10, ACAA1, SCP2 and 1 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, SLC27A2, ACSL4 and 6 moreextracellular space, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC3A2, SLC7A10, CPT1A, CPT1C and 1 moreextracellular space, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• propionyl-CoAReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A10, ACSS3, ACSS2 and 1 moreextracellular space, cytosolOne of 43 routes

• (S)-malateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]

  Catalysed by SLC3A2, SLC7A10, DAO, CLYBLextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC3A2, SLC7A10, SHMT1, SHMT2extracellular space, cytosolOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC3A2, SLC7A10, SHMT1, MTHFD1extracellular space, cytosolOne of 3 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. histamine N-methyltransferase (SAM)

  Catalysed by SLC3A2, SLC7A10, SHMT1, HNMTextracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of D-serine and glutamine (cytosol to extracellular)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC3A2, SLC7A10, SLC7A5, TPH1 and 1 moreextracellular space, cytosolOne of 3 routes