lanosterol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

136 compounds within 3 steps: 4 in 1, 19 in 2, 113 in 3

One step

formateReach from here →
1. lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Catalysed by CYP51A1
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-olReach from here →
1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
Catalysed by CYP4F8cytosolOne of 4 routes
24,25-dihydrolanosterolReach from here →
1. lanosterol delta24-reductase
Catalysed by DHCR24cytosolOne of 2 routes
formic acidReach from here →
1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
Catalysed by CYP4F8cytosolOne of 2 routes

Two steps

2-hydroxybutyric acidReach from here →
1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
acetoacetateReach from here →
1. Cytochrome P450 Lanosterol 14-Alpha-Demethylase (NADP)
2. transport of acetoacetate and formate (cytosol to extracellular)
Catalysed by CYP4F8, SLC16A4, SLC16A5

Three steps

cytosol, extracellular space

One of 2 routes

pyruvateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by CYP4F8, MTHFD1cytosolOne of 2 routes

formaldehydeReach from here →

Catalysed by CYP51A1, ALDH9A1

(R)-3-hydroxybutyric acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-olReach from here →

Catalysed by CYP4F8, TM7SF2cytosol, endoplasmic reticulumOne of 3 routes

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by CYP51A1, MTHFD1, MTHFD1L

chlorine(.)Reach from here →

Catalysed by CYP4F8, SLC26A4cytosol, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

oxalateReach from here →

Catalysed by CYP51A1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

Catalysed by CYP51A1, ADI1One of 2 routes

S-formylglutathioneReach from here →

Catalysed by CYP51A1, ESD

N-formyl-L-kynurenineReach from here →

Catalysed by CYP51A1, AFMID

4,4-dimethyl-8,14-cholestadien-3beta-olReach from here →

Catalysed by DHCR24cytosolOne of 2 routes

Catalysed by CYP4F8, SLC26A4, SLC6A14

cytosol, extracellular space

prostaglandin E3Reach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, CYP26A1cytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, UGT1A1 and 2 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, CYP1A1 and 23 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular space

3-(methylthio)propionic acidReach from here →

Catalysed by CYP51A1, ADI1cytosol

N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

Catalysed by CYP51A1, MTHFD1, MTHFD1L, GART

CHEBI:15345Reach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, AACScytosol, extracellular spaceOne of 3 routes

acetoneReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5cytosol, extracellular space, mitochondrial matrix

cholineReach from here →

Catalysed by CYP4F8, SLC26A4, SLC5A7cytosol, extracellular space

acetylpyruvateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

propionyl-CoAReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular spaceOne of 3 routes

(S)-malateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

L-leucineReach from here →

Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

CHEBI:15971Reach from here →

Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular space

methanethiolReach from here →

Catalysed by CYP51A1, ALDH9A1, SELENBP1

sulfateReach from here →

Catalysed by CYP4F8, SLC26A4, SLC26A6cytosol, extracellular spaceOne of 3 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space, mitochondrial matrix

iodideReach from here →

Catalysed by CYP4F8, SLC26A4cytosol, extracellular space

L-valineReach from here →

Catalysed by CYP4F8, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

oxaloacetateReach from here →

Catalysed by CYP4F8, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes