Compound

24,25-dihydrolanosterol

A 3β-sterol formed from lanosterol by reduction across the C-24‒C-25 double bond.

Definition from ChEBI (CHEBI:28113), read 2026-09-23. CC BY 4.0.

CHEBI:28113ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of 24,25-dihydrolanosterol — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C30H52O
Mass: 428.745 g/mol
Charge: 0
InChIKey: MBZYKEVPFYHDOH-BQNIITSRSA-N
SMILES: [H][C@@]12CCC3=C(CC[C@@]4(C)[C@@]3(C)CC[C@]4([H])[C@H](C)CCCC(C)C)[C@@]1(C)CC[C@H](O)C2(C)C
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

CYP51A1ProteinUNIPROT:Q16850metabolized byInferred only64 paths32 endpoints

What the reference databases state

Chemical structure

24,25-dihydrolanosterol has the functional parent lanosterolCompoundChEBI CHEBI:28113Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: 24,25-dihydrolanosterol · Sources: Human-GEM, Rhea

Order

24,25-dihydrolanosterol is converted to 4,4-dimethyl-8,14-cholestadien-3beta-olCompoundHuman-GEM MAR03536Inferred only
4,4-dimethyl-8,14-cholestadien-3beta-ol is converted to 24,25-dihydrolanosterolCompoundHuman-GEM MAR03536Inferred only
lanosterol is converted to 24,25-dihydrolanosterolCompoundHuman-GEM MAR01535Inferred only
24,25-dihydrolanosterol is metabolised by CYP51A1ProteinRhea RHEA:45960Inferred only
24,25-dihydrolanosterol is metabolised by CYP51A1ProteinHuman-GEM MAR01536Inferred only

Reactions

7 reactions

proton+lanosterol+NADPH(4-)24,25-dihydrolanosterol+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalancedEC 1.3.1.72GO:0005829
Human-GEM MAR01535CC BY 4.0Reference data
24,25-dihydrolanosterol+proton+NADPH(4-)+dioxygenMAM00940c+water+NADP(3-)
Catalysed by CYP51A1
Reaction pageLeft to rightBalancedEC 1.14.14.154GO:0005829
Human-GEM MAR01536CC BY 4.0Reference data
324,25-dihydrolanosterol+carbon dioxide2water+34,4-dimethyl-8,14-cholestadien-3beta-ol+4MAM03357c
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR03536CC BY 4.0Reference data
lanosterol+NADPH(4-)+hydron24,25-dihydrolanosterol+NADP(3-)
Catalysed by DHCR24
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33919CC BY 4.0Reference data
24,25-dihydrolanosterol+3reduced [NADPH--hemoprotein reductase]+3dioxygen4,4-dimethyl-8,14-cholestadien-3beta-ol+formate+3oxidized [NADPH--hemoprotein reductase]+4water+4hydron
Catalysed by CYP51A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45960CC BY 4.0Reference data
24,25-dihydrolanosterol+6reduced [2Fe-2S]-[ferredoxin]+3dioxygen+5hydron4,4-dimethyl-8,14-cholestadien-3beta-ol+formate+6oxidized [2Fe-2S]-[ferredoxin]+4water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56760CC BY 4.0Reference data
24,25-dihydrolanosterol+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:87057+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP51A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:75079CC BY 4.0Reference data

Other names

6 names

Resolves to: 24,25-dihydrolanosterol

Also called: 24-dihydrolanosterol5alpha-lanost-8-en-3beta-olLanostenolST 30:1;O
Systematic name: lanost-8-en-3beta-ollanost-8-en-3β-ol