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4,4-dimethyl-8,14-cholestadien-3beta-ol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

8 compounds within 3 steps: 1 in 1, 1 in 2, 6 in 3

Does it reach a compound?

One step

24,25-dihydrolanosterolReach from here →
1. 24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
No catalyst recordedcytosol

Two steps

formateReach from here →
1. 24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
2. 24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Catalysed by CYP51A1cytosol

Three steps

formaldehydeReach from here →
Catalysed by CYP51A1, ALDH9A1cytosol
(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by CYP51A1, MTHFD1, MTHFD1Lcytosol

oxalateReach from here →

24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
oxalate(in) + formate(out) = oxalate(out) + formate(in)

Catalysed by CYP51A1, SLC26A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

Catalysed by CYP51A1, ADI1cytosolOne of 2 routes

S-formylglutathioneReach from here →

24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
S-formylglutathione + H2O = formate + glutathione + H(+)

Catalysed by CYP51A1, ESDcytosol

N-formyl-L-kynurenineReach from here →

24,25-dihydrolanosterol to 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol conversion
24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

Catalysed by CYP51A1, AFMIDcytosol