Compound
4,4-dimethyl-8,14-cholestadien-3beta-ol
A cholestanoid that is 5α-cholesta-8,14-dien-3β-ol bearing two additional methyl substituents at position 4.
Definition from ChEBI (CHEBI:78904), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound
- Formula
- C29H48O
- Mass
- 412.702 g/mol
- Charge
- 0
- InChIKey
- OGQJUYXFIOFTMA-PBJLWWPKSA-N
- SMILES
- [H][C@@]12CCC3=C(CC[C@@]4(C)C3=CC[C@]4([H])[C@H](C)CCCC(C)C)[C@@]1(C)CC[C@H](O)C2(C)C
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
8 statements
8 statements · 2 reference databases · Subject: 4,4-dimethyl-8,14-cholestadien-3beta-ol · Sources: Human-GEM, Rhea
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is converted to 24,25-dihydrolanosterolCompoundHuman-GEM MAR03536Inferred only
- 24,25-dihydrolanosterol is converted to 4,4-dimethyl-8,14-cholestadien-3beta-olCompoundHuman-GEM MAR03536Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is metabolised by CYP51A1ProteinRhea RHEA:45960Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is metabolised by CYP51A1ProteinRhea RHEA:75083Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is a substrate of LBRProteinHuman-GEM MAR01540Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is a substrate of TM7SF2ProteinHuman-GEM MAR03420Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is a substrate of TM7SF2ProteinHuman-GEM MAR03434Inferred only
- 4,4-dimethyl-8,14-cholestadien-3beta-ol is a substrate of TM7SF2ProteinHuman-GEM MAR01540Inferred only
Reactions
9 reactions
MAM00938c+NADPH(4-)+dioxygen4,4-dimethyl-8,14-cholestadien-3beta-ol+formic acid+water+NADP(3-)
Catalysed by CYP51A1
Reaction pageLeft to rightBalancedEC 1.14.14.154GO:0005829
Human-GEM MAR01539CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+proton+NADPH(4-)MAM00943c+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.3.1.70GO:0005829
Human-GEM MAR01540CC BY 4.0Reference data
proton+NADPH(4-)+4,4-dimethyl-8,14-cholestadien-3beta-olMAM00943c+NADP(3-)
Catalysed by TM7SF2
Reaction pageReversibleBalancedEC 1.3.1.70GO:0005829
Human-GEM MAR03420CC BY 4.0Reference data
proton+NADPH(4-)+4,4-dimethyl-8,14-cholestadien-3beta-olMAM00943r+NADP(3-)
Catalysed by TM7SF2
Reaction pageReversibleBalancedEC 1.3.1.70GO:0005783
Human-GEM MAR03434CC BY 4.0Reference data
324,25-dihydrolanosterol+carbon dioxide2water+34,4-dimethyl-8,14-cholestadien-3beta-ol+4MAM03357c
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR03536CC BY 4.0Reference data
24,25-dihydrolanosterol+3reduced [NADPH--hemoprotein reductase]+3dioxygen4,4-dimethyl-8,14-cholestadien-3beta-ol+formate+3oxidized [NADPH--hemoprotein reductase]+4water+4hydron
Catalysed by CYP51A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45960CC BY 4.0Reference data
4,4-dimethyl-8,14-cholestadien-3beta-ol+NADPH(4-)+hydronCHEBI:87044+NADP(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:46812CC BY 4.0Reference data
24,25-dihydrolanosterol+6reduced [2Fe-2S]-[ferredoxin]+3dioxygen+5hydron4,4-dimethyl-8,14-cholestadien-3beta-ol+formate+6oxidized [2Fe-2S]-[ferredoxin]+4water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56760CC BY 4.0Reference data
32-oxo-24,25-dihydrolanosterol+reduced [NADPH--hemoprotein reductase]+dioxygen4,4-dimethyl-8,14-cholestadien-3beta-ol+formate+oxidized [NADPH--hemoprotein reductase]+water+2hydron
Catalysed by CYP51A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:75083CC BY 4.0Reference data
Other names
10 names
Resolves to: 4,4-dimethyl-8,14-cholestadien-3beta-ol
- Also called
- (3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol(3β,5α)-4,4-dimethylcholesta-8,14-dien-3-ol4,4-Dimethyl-5alpha-cholesta-8,14-diene-3beta-ol4,4-Dimethylcholesta-8,14-dien-3-ol4,4-dimethylcholesta-8,14-dienolDihydro FF-MASdihydro-Follicular fluid meiosis-activating sterolST 29:2;O
- Systematic name
- 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol