oxaloacetate

Three steps

• a triacylglycerolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by CS, ASAH1, ACER2, ACER1 and 6 moremitochondrial matrix, Golgi apparatus, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, SLC7A13, BCAT2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 5 routes

• CHEBI:17895Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and tyrosine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 42 routes

• all-trans-retinalReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 3-oxopropanoic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GAD2, ABATmitochondrial matrix, cytosol

• butanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 9 moremitochondrial matrix, cytosol

• 3-phenylpyruvateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by GOT2, SLC7A13, TATmitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 7 routes

• CHEBI:18019Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by GOT2, ASNS, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 22 routes

• thiocyanateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 3 routes

• 4-fumarylacetoacetateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by FH, FAHmitochondrial matrix, cytosolOne of 2 routes

• triphosphateReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by PCK1, PKM, PKLR, SAMHD1cytosol

• spermine monoaldehydeReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. primary-amine oxidase (spermine)

  Catalysed by CS, SAT1, SAT2, AOC2 and 2 moremitochondrial matrix, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Aspartate Intake by System Asct-1 Transporter
  3. prolyl 4-hydroxylase (AKG)

  Catalysed by GOT2, P4HA2, P4HB, P4HA1mitochondrial matrix, extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. solute carrier (L-carnitine)

  Catalysed by CS, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:18132Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by CS, CHAT, CHKA, CHKBmitochondrial matrix, nucleus, cytosol

• dodecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosol

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. primary-amine oxidase (spermidine)

  Catalysed by CS, SAT1, SAT2, AOC2 and 2 moremitochondrial matrix, cytosolOne of 3 routes

• 2-phenylethylamineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by GOT2, SLC7A13, DDCmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• hydrogen cyanideReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by GOT2, SLC7A13, PFASmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• ophthalmateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by GOT2, SLC7A13, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. Oxaloacetate Decarboxylase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by FAHD1, AGXT2, BCKDHA, BCKDHBcytosol, mitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GOT2, AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. Oxaloacetate Decarboxylase
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by FAHD1, SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• 11-cis-retinyl esterReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by CS, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GOT2, AGXT2mitochondrial matrixOne of 4 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 5 moremitochondrial matrix, cytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CS, CROT, MOGAT2, MOGAT1mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosol

• S-disulfanyl-L-cysteineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CS, NAGS, CARS2mitochondrial matrix

• (S)-lactoyl-AMPReach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 4 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 3 morecytosol

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by CS, CPT1A, CPT1C, CPT1B and 7 moremitochondrial matrix, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CS, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by CS, HADHA, ACADVL, HADHBmitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by CS, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by CS, ECHS1, ACAA2, HADH and 1 moremitochondrial matrixOne of 3 routes

• docosanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. Docosanoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

• dUMPReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. thymidine kinase (deoxyuridine)

  Catalysed by PCK1, PKM, PKLRcytosolOne of 2 routes

• octadecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Stearoyl-CoA hydrolase

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosolOne of 4 routes

• octanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. Octanoyl-CoA hydrolase

  Catalysed by CS, CROT, ACOT7mitochondrial matrix, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes