malonate

Three steps

• 2-oxoadipateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC25A10, FH, ADSL, TNRC6Binner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by SLC25A10, ME2, ME3, MPSTinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 2-methyl-3-oxopropanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

• guanidinoacetateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3',5'-cyclic GMPReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A10, ME2, ME3, TYW1B and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• adenosine 5'-phosphoramidateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, PAPSS1 and 2 moreinner side of the membrane, outer side of the membrane, cytosol

• L-tryptophanReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• glutathioneReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC25A10, TSTD1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• beta-alanineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 21 routes

• L-asparagineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, AGAinner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3',5'-cyclic AMPReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• glutathione disulfideReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC25A10, TSTD1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• L-tyrosineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A14, SLC25A30, SLC25A10, AGXT2inner side of the membrane, outer side of the membrane

• trans-4-hydroxy-L-prolineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, SDHA, PRODH2inner side of the membrane, outer side of the membrane

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A10, FH, ADSLinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• kynurenateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

  Catalysed by SLC25A10, CLYBL, KYAT3, AADATinner side of the membrane, outer side of the membraneOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by SLC25A10, ME2, ME3, CLYBLinner side of the membrane, outer side of the membrane, mitochondrial matrix

• phosphoenolpyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• D-glucosamineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SGSHinner side of the membrane, outer side of the membrane

• 5-amino-2-oxopentanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC25A10, ETHE1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-prolineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, SDHA, PRODH and 1 moreinner side of the membrane, outer side of the membrane

• prostaglandin E2Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A12 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by SLC25A10, ME2, ME3, HOGA1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• ubiquinol-10Reach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC25A10, SQORinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• xanthurenateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by SLC25A10, CLYBL, KYAT3, AADATinner side of the membrane, outer side of the membrane

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by SLC25A10, ME2, ME3, HOGA1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• beta-citrylglutamateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A10, SLC25A1, RIMKLBinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STS and 1 moreinner side of the membrane, outer side of the membrane

• 3-methylmalateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by SLC25A10, CLYBLinner side of the membrane, outer side of the membrane

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by SLC25A10, ME2, ME3, PDHA1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix