arachidonoyl-CoA

Three steps

• a (3S)-3-hydroxyacyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 3 morecytosol

• (2E)-butenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol, mitochondrial matrixOne of 4 routes

• 3-methyl-(2E)-glutaconyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)
  3. 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol

• (2E)-glutaconyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol

• acryloyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Propanoate:CoA ligase (AMP-forming)
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, mitochondrial matrix

• hexadecanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase
  3. (2E)-hexadecenoyl-CoA + NADPH + H(+) = hexadecanoyl-CoA + NADP(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosolOne of 2 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• propanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• prostaglandin E1Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin I2Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 6 routes

• prostaglandin F2alphaReach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 6 routes

• prostaglandin D2Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 7 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. arachidonate:oxygen 15-oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 12 morecytosolOne of 4 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosolOne of 2 routes

• D-alanineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

• thromboxane A2Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. prostaglandin-endoperoxide synthase (arachidonate)
  3. thromboxane A synthase (prostaglandin H2)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, endoplasmic reticulumOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, mitochondrial matrix

• (R)-S-lactoylglutathioneReach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, extracellular spaceOne of 2 routes

• propane-1,3-diamineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosolOne of 2 routes

• a long-chain fatty acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by GNPAT, AGPScytosol

• O-acetyl-(R)-carnitineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Utilized Transport
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, endoplasmic reticulumOne of 9 routes

• ethanolamineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 5 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• S-formylglutathioneReach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosol, extracellular space

• guanidinoacetateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• D-threonineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)

  Catalysed by LCLAT1, MBOAT7, PIKFYVEcytosol

• sphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosol

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosolOne of 12 routes

• CDP-ethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 2 routes

• L-tryptophanReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• glutathioneReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix

• L-threonineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-kynurenineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• leukotriene C4Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, extracellular spaceOne of 10 routes

• taurocyamineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)

  Catalysed by LCLAT1, MBOAT7, PIK3CD, PIK3C2A and 5 morecytosol

• L-cysteateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. L-cysteate + H(+) = taurine + CO2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

• L-phenylalanineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosolOne of 29 routes

• N(1)-acetylspermineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G1B and 27 morecytosolOne of 14 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes