Loading the page.
Proteins/UNIPROT:P04054
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity)..
Function from UniProtKB (P04054), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
58 statements
58 statements · 9 reference databases · Subject: PLA2G1B · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
15 reactions
5 names
Resolves to: PLA2G1B
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum
Human-GEM MAR00463CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00630CC BY 4.0Reference data
water+phosphatidylethanolamineMAM00511c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00643CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome
Human-GEM MAR05254CC BY 4.0Reference data
water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07603CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07615CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:38779CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40427CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z,12Z)-octadecadienoate+hydron
Catalysed by PLA2G10 or PLA2G1B or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT2 or PLA2G3 or PLA2G2E and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40815CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)+water1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)+(9Z)-octadecenoate+hydron
Catalysed by ABHD16A or PLA2G1B or PLA2G2A or PLB1 or PLA2G15 or PLA2G2F or PLA2G2D
Reaction pageLeft to rightBalanced
Rhea RHEA:40919CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PRDX6 or PLAAT3 or PLB1 or PLA2G15 or PLAAT1 or PLAAT2 or PLA2G2E or PLAAT4 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:41223CC BY 4.0Reference data