an N(2)-acyl-L-glutamine

Three steps

• 2-oxobutanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 3 moreextracellular space, cytosolOne of 2 routes

• tryptamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, DDCextracellular space, cytosol

• CHEBI:16856Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, SLC26A6extracellular space, cytosol

• 3-hydroxypyruvateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+)

  Catalysed by GLYATL1B, GLYATL1, SLC1A5, DAOinner side of the membrane, outer side of the membrane

• L-glutamic 5-semialdehydeReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GLYATL1B, GLYATL1, NUDT19cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GLYATL1B, GLYATL1, NUDT19cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GLYATL1B, GLYATL1, NUDT19cytosol

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1, CERS1cytosol

• myo-inositolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)

  Catalysed by GLYATL1B, GLYATL1, LCLAT1, MBOAT7 and 1 more

• anilineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA
  3. carboxylesterase (retinyl-ester)

  Catalysed by GLYATL1B, GLYATL1, DGAT1, PNPLA4 and 21 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Linoleoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 3 morecytosol

• CHEBI:17380Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by GLYATL1B, GLYATL1, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• a 2-acylglycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, MOGAT2, AWAT2 and 4 more

• a monoacylglycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. 1,2-diacyl-sn-glycerol acylhydrolase

  Catalysed by GLYATL1B, GLYATL1, MOGAT2, AWAT2 and 16 moreextracellular spaceOne of 8 routes

• agmatineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6extracellular space, cytosol, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by GLYATL1B, GLYATL1, CPT2, CPT1Acytosol, peroxisomeOne of 4 routes

• AH2Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GLYATL1B, GLYATL1, KYAT1, MOCOScytosolOne of 4 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 20 morecytosol, endoplasmic reticulumOne of 8 routes

• 5-aminolevulinic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, ALAS1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• a sphingomyelinReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 4 morecytosol, Golgi apparatusOne of 5 routes

• indole-3-pyruvateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, IL4I1extracellular space, cytosolOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, AARS1cytosol

• glycine betaineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• glycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  3. a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol

  Catalysed by GLYATL1B, GLYATL1, MOGAT2, MOGAT3 and 6 moreOne of 2 routes

• trans-urocanateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, HALextracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TPH1 and 1 moreextracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by GLYATL1B, GLYATL1, KYAT1cytosolOne of 6 routes

• a diacylglycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, DGAT1, MOGAT2 and 22 morecytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC1A4cytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Transport of 3-Ureidopropionate

  Catalysed by GLYATL1B, GLYATL1, SLC6A14extracellular space, cytosolOne of 2 routes

• dodecanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Lauroyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 2 morecytosolOne of 2 routes

• phosphatidyl-L-serineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylserine synthase (PC-LD pool)

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 3 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. phosphoribosyl pyrophosphate amidotransferase (glutamine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GLYATL1B, GLYATL1, PPAT, GARTcytosolOne of 2 routes

• 2-phenylethylamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, DDCextracellular space, cytosol

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by GLYATL1B, GLYATL1, ACOX1cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by GLYATL1B, GLYATL1, LPGAT1cytosol

• ophthalmateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by GLYATL1B, GLYATL1, SLC1A5, SLC7A10inner side of the membrane, outer side of the membrane