a sphingomyelin

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

427 compounds within 3 steps: 8 in 1, 81 in 2, 338 in 3

One step

CHEBI:16436Reach from here →
1. ceramide cholinephosphotransferase (CDP-choline)
No catalyst recordedendoplasmic reticulum
CHEBI:18132Reach from here →
1. Sphingomyelin cholinephosphohydrolase
Catalysed by SMPD2, SMPD1, ENPP7, SMPD4 and 1 morecytosolOne of 4 routes
phosphocholineReach from here →
1. a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)
Catalysed by SMPD2, SMPD1, ENPP7, SMPD4 and 1 more
fatty acidReach from here →
1. SM pool hydrolysis
No catalyst recordedcytosol
an N-acylsphing-4-enineReach from here →
1. ceramide cholinephosphotransferase (CDP-choline)
No catalyst recordedendoplasmic reticulumOne of 9 routes
a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
Catalysed by SGMS1, SGMS2
1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by SGMS2
a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by SGMS1, SGMS2

Two steps

Reach from here →

Catalysed by SGMS2, PLAAT2

1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamineReach from here →

Catalysed by SGMS2, PLA2G4E

an N-acyl-sphinga-4E,14Z-dienineReach from here →

Catalysed by FADS3endoplasmic reticulum

cholineReach from here →

Catalysed by SMPD2, SMPD1, ENPP7, SMPD4 and 2 morecytosolOne of 6 routes

hexadecanoic acidReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

Catalysed by CHPT1, CEPT1endoplasmic reticulum, cytosol

cholesterolReach from here →

Catalysed by GBA1, GBA2endoplasmic reticulumOne of 3 routes

sn-glycerol 3-phosphocholineReach from here →

Catalysed by SGMS2, PLB1

linoleic acidReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

all-trans-retinyl hexadecanoateReach from here →

Catalysed by SGMS2, LRATOne of 2 routes

a 1,2-diacyl-sn-glycerolReach from here →

Catalysed by SGMS1, SGMS2endoplasmic reticulum, Golgi apparatusOne of 12 routes

a triacylglycerolReach from here →

Catalysed by SGMS1, SGMS2, TMEM68

dodecanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

D-glucosyl-N-acylsphingosineReach from here →

Catalysed by UGCGendoplasmic reticulum, cytosolOne of 2 routes

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by UGT8endoplasmic reticulumOne of 2 routes

a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by GBA1, GBA3endoplasmic reticulumOne of 2 routes

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by UGCGendoplasmic reticulumOne of 2 routes

docosanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

octadecanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

alpha-linolenic acidReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

elaidic acidReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

a fatty acidReach from here →

Catalysed by NAAA, ASAH1, ACER2, ACER1 and 2 moreendoplasmic reticulumOne of 4 routes

tetradecanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

(9Z)-octadecenoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 13 routes

hexacosanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

tetracosanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

an N-acylsphinganineReach from here →

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol

eicosanoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

(9Z)-hexadecenoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

(15Z)-tetracosenoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

(11Z)-eicosenoateReach from here →

No catalyst recordedcytosol, extracellular spaceOne of 12 routes

a sterol esterReach from here →

Catalysed by SGMS1, SGMS2, LCAT

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by CHPT1, CEPT1endoplasmic reticulum, cytosol

a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by CHPT1, CEPT1endoplasmic reticulum, cytosol

a 1,3-diacylglycerolReach from here →

Catalysed by SGMS1, SGMS2, PLA2G15One of 4 routes

a 1,2-diacylglycerolReach from here →

Catalysed by SGMS1, SGMS2, PLA2G15One of 2 routes

a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →

Catalysed by SGMS1, SGMS2, PTDSS1

an N-acylsphing-4-enine 1-phosphateReach from here →

Catalysed by AGK, CERKendoplasmic reticulum