O-tetradecanoyl-(R)-carnitine

Three steps

• CHEBI:27540Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by CPT2, SLC22A5, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• adipic acidReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• an N-acylsphinganineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CPT2, CERS1, CERS6, CERS3 and 3 morecytosol

• fatty acidReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 4 routes

• taurocholateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• cholesteryl hexadecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by CPT2, SOAT2, SOAT1cytosol, endoplasmic reticulum

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by CPT2, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

• a 1,3-diacylglycerolReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by CPT2, MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by CPT2, MOGAT2, MOGAT3, LPGAT1 and 2 morecytosolOne of 2 routes

• taurineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by CPT2, LPCAT4, LPCAT3, MBOAT1cytosol

• glycineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• (R)-methylmalonyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosol, mitochondrial matrixOne of 8 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 8 routes

• butanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 8 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membraneOne of 6 routes

• hexadecanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CPT1A, CPT1B

• eicosanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
  3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA

  Catalysed by CPT2One of 14 routes

• itaconyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 14 routes

• octanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CPT2, CRAT, CROTmitochondrial matrixOne of 25 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA

  Catalysed by CPT2

• phytanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
  3. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA

  Catalysed by CPT2One of 18 routes

• prostaglandin F2alphaReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by CPT2, GPAT3, GPAT2, GPAT4 and 1 morecytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by CPT2, GNPATcytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, LPGAT1cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by CPT2, GLYATL3, GLYAT, GLYATL2cytosol

• sphing-4-enineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 6 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by CPT2, SLC22A5, BHMT, BHMT2inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by CPT2, LCLAT1, MBOAT7cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by CPT2, GPAT3, GPAT2, GPAT4 and 1 morecytosol

• L-alanineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

• N,N-dimethylglycineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

  Catalysed by CPT2, SLC22A5, BHMTinner side of the membrane, outer side of the membrane

• 3-oxosphinganineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by CPT2, SPTLC1, SPTLC2, SPTLC3cytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by CPT2, GNPATcytosol, peroxisome

• kynurenateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes