L-cysteinylglycine

Two steps

• Gly-tRNA(Gly)Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, GARS1cytosol

• chlorine(.)Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC6A14cytosol, extracellular spaceOne of 7 routes

• glycocholateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, BAATcytosol, peroxisomeOne of 6 routes

• cholateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 3 routes

• hydrogen sulfideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by ANPEP, LAP3, NPEPPS, CTHcytosolOne of 3 routes

• L-aspartateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• an alcoholReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, CP, PRDX6

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 morecytosol, extracellular spaceOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. De novo synthesis of 2Fe2S

  Catalysed by ANPEP, LAP3, NPEPPS, NDUFAB1 and 6 morecytosol, mitochondrial matrix

• serotoninReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 2 routes

• D-cysteineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 5-aminolevulinateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ANPEP, LAP3, NPEPPS, ALAS1 and 1 morecytosol

• glycochenodeoxycholateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, BAATcytosolOne of 2 routes

• taurocholateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. solute carrier organic anion transporter (GSH)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 3 routes

• glycochenodeoxycholic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by ANPEP, LAP3, NPEPPS, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by ANPEP, LAP3, NPEPPS, BAATcytosolOne of 4 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, GCATcytosol, mitochondrial matrix

• tert-butanolReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, CLIC2, GPX1 and 3 more

• L-ornithineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6cytosol, extracellular spaceOne of 10 routes

• gamma-Glu-AlaReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by ANPEP, LAP3, NPEPPS, GLDC and 1 morecytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E1Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 11 morecytosolOne of 2 routes

• D-alanineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ANPEP, LAP3, NPEPPS, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ANPEP, LAP3, NPEPPS, SHMT1 and 1 morecytosol

• leukotriene A4Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosolOne of 3 routes

• an N-acylglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, GLYATL3 and 2 morecytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by ANPEP, LAP3, NPEPPS, GOT2 and 1 morecytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. alcohol dehydrogenase (formaldehyde)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 8 morecytosolOne of 2 routes

• guanidinoacetateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-Arginine:glycine amidinotransferase

  Catalysed by ANPEP, LAP3, NPEPPS, GATMcytosolOne of 2 routes

• D-threonineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 18 routes

• L-tryptophanReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 13 routes

• L-threonineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-kynurenineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• beta-alanineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• leukotriene C4Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. leukotriene C4 hydrolysis

  Catalysed by ANPEP, LAP3, NPEPPScytosolOne of 6 routes

• L-asparagineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 14 routes

• L-phenylalanineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 19 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, GCLC and 1 morecytosolOne of 2 routes