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Proteins/UNIPROT:P55786
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain..
Function from UniProtKB (P55786), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
54 statements
54 statements · 5 reference databases · Subject: NPEPPS · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt
2 reactions
L-cysteinylglycine+waterL-cysteine+glycine
Catalysed by LAP3 or NPEPPS or ANPEP
Reaction pageLeft to rightBalancedEC 3.4.11.1, 3.4.11.2cytosol
Human-GEM MAR04328CC BY 4.0Reference data
3 names
Resolves to: NPEPPS
Reaction pageLeft to rightBalancedEC 3.4.11.1, 3.4.11.2extracellular space
Human-GEM MAR04329CC BY 4.0Reference data