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Proteins/UNIPROT:P15144
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity)..
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein..
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection..
Function from UniProtKB (P15144), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
76 statements
76 statements · 5 reference databases · Subject: ANPEP · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
2 reactions
L-cysteinylglycine+waterL-cysteine+glycine
Catalysed by LAP3 or NPEPPS or ANPEP
Reaction pageLeft to rightBalancedEC 3.4.11.1, 3.4.11.2cytosol
Human-GEM MAR04328CC BY 4.0Reference data
12 names
Resolves to: ANPEP
Reaction pageLeft to rightBalancedEC 3.4.11.1, 3.4.11.2extracellular space
Human-GEM MAR04329CC BY 4.0Reference data