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deamido-NAD(+)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

20 compounds within 3 steps: 2 in 1, 4 in 2, 14 in 3

Does it reach a compound?

One step

nicotinic acid D-ribonucleotideReach from here →
1. Deamino-NAD+ nucleotidohydrolase
Catalysed by ENPP3, ENPP1, NUDT12cytosol
nicotinate beta-D-ribonucleotideReach from here →
1. nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
Catalysed by NMNAT3, NMNAT2, NMNAT1

Two steps

quinolinateReach from here →
1. nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
2. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT
nicotinateReach from here →
1. nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
2. 5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRT

Three steps

CHEBI:15842Reach from here →
Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 morecytosol
nicotinic acidReach from here →

5-phospho-alpha-D-ribose 1-diphosphateReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRTOne of 2 routes

beta-D-ribosylnicotinateReach from here →

Deamino-NAD+ nucleotidohydrolase
nicotinate D-ribonucleotide phosphohydrolase

Catalysed by ENPP3, ENPP1, NUDT12, ACP3 and 7 morecytosolOne of 2 routes

Catalysed by ENPP3, ENPP1, NUDT12, ACP3 and 7 more

cytosol

NMN zwitterionReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 morecytosolOne of 2 routes

nicotinamideReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
nicotinate + NADP(+) = NAADP(+) + nicotinamide

Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRT and 1 more

CHEBI:17202Reach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
IMP:diphosphate phospho-D-ribosyltransferase

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 morecytosol

urateReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRT and 2 moreinner side of the membrane, outer side of the membrane

orotateReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRT and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

D-ribose 1-phosphateReach from here →

Deamino-NAD+ nucleotidohydrolase
nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase

Catalysed by ENPP3, ENPP1, NUDT12, ACP3 and 7 morecytosol

XMPReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
XMP:pyrophosphate phosphoribosyltransferase

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 morecytosol

orotidine 5'-phosphateReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 more

IMPReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 more

5-phospho-beta-D-ribosylamineReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 morecytosolOne of 2 routes

alpha-D-ribose 1,5-bisphosphateReach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
5-phospho-alpha-D-ribose 1-diphosphate + H2O = alpha-D-ribose 1,5-bisphosphate + phosphate + H(+)

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRT and 1 more

NAADP(+)Reach from here →

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
nicotinate + NADP(+) = NAADP(+) + nicotinamide

Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRT and 1 moreOne of 2 routes