Compound
5-phospho-alpha-D-ribose 1-diphosphate
Pentaanion of 5-O-phosphono-α-D-ribofuranosyl diphosphate arising from deprotonation of the phosphate and diphosphate OH groups; major species at pH 7.3.
Definition from ChEBI (CHEBI:58017), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C5H8O14P3
- Mass
- 385.027 g/mol
- Charge
- -5
- InChIKey
- PQGCEDQWHSBAJP-TXICZTDVSA-I
- SMILES
- O=P([O-])([O-])OC[C@H]1O[C@H](OP(=O)([O-])OP(=O)([O-])[O-])[C@H](O)[C@@H]1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- HPRT1ProteinUNIPROT:P00492substrate ofInferred only135 paths27 endpoints
- APRTProteinUNIPROT:P07741substrate ofInferred only66 paths22 endpoints
- NAMPTProteinUNIPROT:P43490substrate ofInferred only42 paths21 endpoints
- UMPSProteinUNIPROT:P11172substrate ofInferred only26 paths13 endpoints
- PPATProteinUNIPROT:Q06203substrate ofInferred only22 paths11 endpoints
- QPRTProteinUNIPROT:Q15274substrate ofInferred only22 paths11 endpoints
- NAPRTProteinUNIPROT:Q6XQN6substrate ofInferred only18 paths9 endpoints
- NUDT4ProteinUNIPROT:Q9NZJ9substrate ofInferred only3 paths3 endpoints
- UPRTProteinUNIPROT:Q96BW1substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
25 statements
25 statements · 2 reference databases · Subject: 5-phospho-alpha-D-ribose 1-diphosphate · Sources: Human-GEM, Rhea
- alpha-D-ribose 1,5-bisphosphate is converted to 5-phospho-alpha-D-ribose 1-diphosphateCompoundRhea RHEA:20109Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is converted to alpha-D-ribose 1,5-bisphosphateCompoundRhea RHEA:80811Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is converted to alpha-D-ribose 1,5-bisphosphateCompoundRhea RHEA:20109Inferred only
- CHEBI:17797 is converted to 5-phospho-alpha-D-ribose 1-diphosphateCompoundHuman-GEM MAR04052Inferred only
- D-ribose 5-phosphate is converted to 5-phospho-alpha-D-ribose 1-diphosphateCompoundRhea RHEA:15609Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of APRTProteinHuman-GEM MAR04085Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of APRTProteinRhea RHEA:16609Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of APRTProteinHuman-GEM MAR04086Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of HPRT1ProteinHuman-GEM MAR04418Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of HPRT1ProteinRhea RHEA:17973Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of HPRT1ProteinHuman-GEM MAR04452Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of HPRT1ProteinHuman-GEM MAR04664Inferred only
Show the remaining 13
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of HPRT1ProteinRhea RHEA:25424Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of NAMPTProteinRhea RHEA:16149Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of NAMPTProteinHuman-GEM MAR04262Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of NAPRTProteinHuman-GEM MAR04254Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of NAPRTProteinRhea RHEA:36163Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of NUDT4ProteinRhea RHEA:80811Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of PPATProteinRhea RHEA:14905Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of PPATProteinHuman-GEM MAR04406Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of QPRTProteinRhea RHEA:12733Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of QPRTProteinHuman-GEM MAR04251Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of UMPSProteinRhea RHEA:10380Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of UMPSProteinHuman-GEM MAR04577Inferred only
- 5-phospho-alpha-D-ribose 1-diphosphate is a substrate of UPRTProteinHuman-GEM MAR04343Inferred only
Reactions
35 reactions
5-phospho-alpha-D-ribose 1-diphosphate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01984CC BY 4.0Reference data
ATP+CHEBI:17797AMP+proton+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by PRPS2 or PRPS1 or PRPS1L1
Reaction pageLeft to rightBalancedEC 2.7.6.1cytosol
Human-GEM MAR04052CC BY 4.0Reference data
adenine+5-phospho-alpha-D-ribose 1-diphosphateAMP+diphosphate(3-)
Catalysed by APRT
Reaction pageLeft to rightBalancedEC 2.4.2.7cytosol
Human-GEM MAR04085CC BY 4.0Reference data
adenine+5-phospho-alpha-D-ribose 1-diphosphateAMP+diphosphate(3-)
Catalysed by APRT
Reaction pageLeft to rightBalancedEC 2.4.2.7extracellular space
Human-GEM MAR04086CC BY 4.0Reference data
2proton+5-phospho-alpha-D-ribose 1-diphosphate+quinolinic acidcarbon dioxide+nicotinic acid D-ribonucleotide+diphosphate(3-)
Catalysed by QPRT
Reaction pageLeft to rightBalancedEC 2.4.2.19cytosol
Human-GEM MAR04251CC BY 4.0Reference data
proton+nicotinic acid+5-phospho-alpha-D-ribose 1-diphosphatenicotinic acid D-ribonucleotide+diphosphate(3-)
Catalysed by NAPRT
Reaction pageLeft to rightBalancedEC 6.3.4.21cytosol
Human-GEM MAR04254CC BY 4.0Reference data
proton+nicotinamide+5-phospho-alpha-D-ribose 1-diphosphateNMN zwitterion+diphosphate(3-)
Catalysed by NAMPT
Reaction pageLeft to rightBalancedEC 2.4.2.12cytosol
Human-GEM MAR04262CC BY 4.0Reference data
5-phospho-alpha-D-ribose 1-diphosphate+uracildiphosphate(3-)+UMP
Catalysed by UPRT
Reaction pageLeft to rightBalancedEC 2.4.2.9cytosol
Human-GEM MAR04343CC BY 4.0Reference data
L-glutamine+water+5-phospho-alpha-D-ribose 1-diphosphate5-phospho-beta-D-ribosylamine+L-glutamate(1-)+diphosphate(3-)
Catalysed by PPAT
Reaction pageLeft to rightBalancedEC 2.4.2.14cytosol
Human-GEM MAR04406CC BY 4.0Reference data
hypoxanthine+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:17202+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
Human-GEM MAR04418CC BY 4.0Reference data
guanine+5-phospho-alpha-D-ribose 1-diphosphateGMP+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
Human-GEM MAR04452CC BY 4.0Reference data
orotic acid+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:15842+diphosphate(3-)
Catalysed by UMPS
Reaction pageLeft to rightBalancedEC 2.4.2.10cytosol
Human-GEM MAR04577CC BY 4.0Reference data
Other names
4 names
Resolves to: 5-phospho-alpha-D-ribose 1-diphosphate
- Also called
- 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate pentaanion5-O-phosphonato-α-D-ribofuranosyl diphosphate pentaanion5-phosphonatoribosyl 1-pyrophosphate5-phosphoribosyl 1-pyrophosphate