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Reference

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nicotinic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

5 compounds within 3 steps: 1 in 1, 2 in 2, 2 in 3

Does it reach a compound?

One step

nicotinic acid D-ribonucleotideReach from here →
1. nicotinate phosphoribosyltransferase (nicotinate)
Catalysed by NAPRTcytosol

Two steps

deamido-NAD(+)Reach from here →
1. nicotinate phosphoribosyltransferase (nicotinate)
2. Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
Catalysed by NAPRT, NMNAT3cytosol, mitochondrial matrixOne of 3 routes
beta-D-ribosylnicotinateReach from here →
1. nicotinate phosphoribosyltransferase (nicotinate)
2. nicotinate D-ribonucleotide phosphohydrolase
Catalysed by NAPRT, ACP3, NT5E, NT5C and 5 morecytosol

Three steps

D-ribose 1-phosphateReach from here →
Catalysed by NAPRT, ACP3, NT5E, NT5C and 5 morecytosol
nicotinate beta-D-ribonucleotideReach from here →

Catalysed by NAPRT, NMNAT3, NMNAT2, NMNAT1

cytosol, mitochondrial matrix

One of 2 routes