Compound

deamido-NAD(+)

Dianion of deamido-NAD+ arising from deprotonation of phosphate and carboxylic acid functions.

Definition from ChEBI (CHEBI:58437), read 2026-09-23. CC BY 4.0.

CHEBI:58437ChEBI

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Structure

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A generated conformer of deamido-NAD(+) — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C21H24N6O15P2
Mass: 662.398 g/mol
Charge: -2
InChIKey: SENPVEZBRZQVST-HISDBWNOSA-L
SMILES: Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OC[C@H]2O[C@@H]([n+]3cccc(C(=O)[O-])c3)[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

7 entities

7 entities reached.

0 reported hops7 assembled from the scaffold

What the reference databases state

Statements

16 statements

16 statements · 2 reference databases · Subject: deamido-NAD(+) · Sources: Human-GEM, Rhea

Order

deamido-NAD(+) is converted to nicotinate beta-D-ribonucleotideCompoundRhea RHEA:22860Inferred only
nicotinate beta-D-ribonucleotide is converted to deamido-NAD(+)CompoundRhea RHEA:22860Inferred only
deamido-NAD(+) is converted to nicotinic acid D-ribonucleotideCompoundHuman-GEM MAR04255Inferred only
nicotinic acid D-ribonucleotide is converted to deamido-NAD(+)CompoundHuman-GEM MAR01554Inferred only
nicotinic acid D-ribonucleotide is converted to deamido-NAD(+)CompoundHuman-GEM MAR04257Inferred only
nicotinic acid D-ribonucleotide is converted to deamido-NAD(+)CompoundHuman-GEM MAR04276Inferred only
deamido-NAD(+) is a substrate of ENPP1ProteinHuman-GEM MAR04255Inferred only
deamido-NAD(+) is a substrate of ENPP3ProteinHuman-GEM MAR04255Inferred only
deamido-NAD(+) is a substrate of NADSYN1ProteinHuman-GEM MAR04278Inferred only
deamido-NAD(+) is a substrate of NADSYN1ProteinRhea RHEA:24384Inferred only
deamido-NAD(+) is a substrate of NADSYN1ProteinHuman-GEM MAR04260Inferred only
deamido-NAD(+) is a substrate of NADSYN1ProteinHuman-GEM MAR04261Inferred only

Show the remaining 4

deamido-NAD(+) is a substrate of NMNAT1ProteinRhea RHEA:22860Inferred only
deamido-NAD(+) is a substrate of NMNAT2ProteinRhea RHEA:22860Inferred only
deamido-NAD(+) is a substrate of NMNAT3ProteinRhea RHEA:22860Inferred only
deamido-NAD(+) is a substrate of NUDT12ProteinHuman-GEM MAR04255Inferred only

Reactions

14 reactions

ATP+proton+nicotinic acid D-ribonucleotidedeamido-NAD(+)+diphosphate(3-)
Catalysed by NMNAT3
Reaction pageLeft to rightBalancedEC 2.7.7.18mitochondrial matrix
Human-GEM MAR01554CC BY 4.0Reference data
deamido-NAD(+)+waterAMP+2proton+nicotinic acid D-ribonucleotide
Catalysed by NUDT12 or ENPP3 or ENPP1
Reaction pageLeft to rightBalancedEC 3.6.1.22, 3.6.1.9cytosol
Human-GEM MAR04255CC BY 4.0Reference data
ATP+proton+nicotinic acid D-ribonucleotidedeamido-NAD(+)+diphosphate(3-)
Catalysed by NMNAT2 or NMNAT3 or NMNAT1
Reaction pageLeft to rightBalancedEC 2.7.7.1, 2.7.7.18cytosol
Human-GEM MAR04257CC BY 4.0Reference data
ATP+deamido-NAD(+)+L-glutamine+waterAMP+L-glutamate(1-)+proton+NAD(+)+diphosphate(3-)
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1cytosol
Human-GEM MAR04260CC BY 4.0Reference data
ATP+deamido-NAD(+)+ammoniumAMP+NAD(+)+diphosphate(3-)
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1cytosol
Human-GEM MAR04261CC BY 4.0Reference data
deamido-NAD(+)deamido-NAD(+)
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR04274CC BY 4.0Reference data
ATP+proton+nicotinic acid D-ribonucleotidedeamido-NAD(+)+diphosphate(3-)
Catalysed by NMNAT1
Reaction pageLeft to rightBalancedEC 2.7.7.1nucleus
Human-GEM MAR04276CC BY 4.0Reference data
ATP+deamido-NAD(+)+ammoniumAMP+NAD(+)+diphosphate(3-)
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1nucleus
Human-GEM MAR04278CC BY 4.0Reference data
deamido-NAD(+)+ammonium+ATP(4-)AMP+diphosphate(3-)+NAD(1-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:21188CC BY 4.0Reference data
nicotinate beta-D-ribonucleotide+ATP(4-)+hydrondeamido-NAD(+)+diphosphate(3-)
Catalysed by NMNAT3 or NMNAT2 or NMNAT1
Reaction pageReversibleBalanced
Rhea RHEA:22860CC BY 4.0Reference data
deamido-NAD(+)+L-glutamine+ATP(4-)+waterL-glutamate(1-)+AMP+diphosphate(3-)+NAD(1-)+hydron
Catalysed by NADSYN1
Reaction pageLeft to rightBalanced
Rhea RHEA:24384CC BY 4.0Reference data
deamido-NAD(+)+hydrogencarbonateCHEBI:137353+AMP+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:54756CC BY 4.0Reference data

Show the remaining 2

Other names

5 names

Resolves to: deamido-NAD(+)

Also called: NaAD(2-)NaAD(2−)nicotinic acid adenine dinucleotide(2-)nicotinic acid adenine dinucleotide(2−)
Systematic name: adenosine 5'-{3-[1-(3-carboxypyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}