Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

2'-phospho-cyclic ADP-ribose

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

11 compounds within 3 steps: 1 in 1, 3 in 2, 7 in 3

Does it reach a compound?

One step

NAADP(+)Reach from here →
1. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
Catalysed by CD38

Two steps

NAADPHReach from here →
1. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
2. NAADPH + O2 + H(+) = NAADP(+) + H2O2
Catalysed by CD38, DUOX2, DUOX1One of 3 routes
nicotinateReach from here →
1. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
2. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
Catalysed by CD38
6-phospho-D-glucono-1,5-lactoneReach from here →
1. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
2. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by CD38, G6PD

Three steps

nicotinamideReach from here →
Catalysed by CD38
urateReach from here →
Catalysed by CD38, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane

superoxideReach from here →

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
NAADPH + O2 + H(+) = NAADP(+) + H2O2
NAADPH + 2 O2 = NAADP(+) + 2 superoxide + H(+)

Catalysed by CD38, DUOX2, DUOX1, NOX5

orotateReach from here →

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

Catalysed by CD38, SLC22A12inner side of the membrane, outer side of the membraneOne of 2 routes

D-glucopyranose 6-phosphateReach from here →

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
D-glucose-6-phosphate:NAD+ 1-oxidoreductase

Catalysed by CD38, G6PD, H6PDendoplasmic reticulum

nicotinate beta-D-ribonucleotideReach from here →

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate

Catalysed by CD38, NAPRT

D-glucose 6-phosphateReach from here →

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)
NAADPH + O2 + H(+) = NAADP(+) + H2O2
NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

Catalysed by CD38, DUOX2, DUOX1, G6PDOne of 2 routes