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dIMP

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

24 compounds within 3 steps: 2 in 1, 6 in 2, 16 in 3

Does it reach a compound?

One step

2'-deoxyinosineReach from here →
1. 5', 3'-nucleotidase (dIMP)
Catalysed by NT5CcytosolOne of 3 routes
IMPReach from here →
1. dIMP + inosine = 2'-deoxyinosine + IMP
Catalysed by NT5C2

Two steps

hypoxanthineReach from here →
1. 5', 3'-nucleotidase (dIMP)
2. Deoxyinosine:orthophosphate ribosyltransferase
Catalysed by NT5C, PNPcytosolOne of 2 routes
inosineReach from here →
1. 5', 3'-nucleotidase (dIMP)
2. dIMP + inosine = 2'-deoxyinosine + IMP
Catalysed by NT5C, NT5C2cytosolOne of 8 routes
2-deoxy-alpha-D-ribose 1-phosphateReach from here →

Three steps

CHEBI:16174Reach from here →
Catalysed by NT5C2mitochondrial matrix
adenosineReach from here →
Catalysed by NT5C, NT5C2cytosol, extracellular spaceOne of 3 routes

5', 3'-nucleotidase (dIMP)

2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

Catalysed by NT5C, PNPcytosol

XMPReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
IMP + NAD(+) + H2O = XMP + NADH + H(+)

Catalysed by NT5C2, IMPDH2, IMPDH1

N(6)-(1,2-dicarboxyethyl)-AMPReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

Catalysed by NT5C2, ADSS2, ADSS1

dGMPReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
dGMP + inosine = 2'-deoxyguanosine + IMP

Catalysed by NT5C2

Reach from here →

5', 3'-nucleotidase (dIMP)
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + UMP = uridine + IMP

Catalysed by NT5C, NT5C2cytosol

guanosineReach from here →

5', 3'-nucleotidase (dIMP)
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + GMP = guanosine + IMP

Catalysed by NT5C, NT5C2cytosol

2'-deoxyguanosineReach from here →

5', 3'-nucleotidase (dIMP)
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Catalysed by NT5C, PNPcytosolOne of 7 routes

CHEBI:17202Reach from here →

5', 3'-nucleotidase (dIMP)
Deoxyinosine:orthophosphate ribosyltransferase
IMP:diphosphate phospho-D-ribosyltransferase

Catalysed by NT5C, PNP, HPRT1cytosolOne of 3 routes

cytidineReach from here →

5', 3'-nucleotidase (dIMP)
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + CMP = cytidine + IMP

Catalysed by NT5C, NT5C2cytosol

xanthineReach from here →

5', 3'-nucleotidase (dIMP)
Deoxyinosine:orthophosphate ribosyltransferase
hypoxanthine:NAD+ oxidoreductase

Catalysed by NT5C, PNP, XDHcytosolOne of 4 routes

fumaric acidReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Catalysed by NT5C2, ADSS2, ADSS1, ADSL and 1 morecytosolOne of 2 routes

xanthosineReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
IMP + NAD(+) + H2O = XMP + NADH + H(+)
xanthosine 5'-phosphate phosphohydrolase

Catalysed by NT5C2, IMPDH2, IMPDH1, ACP3 and 6 morecytosolOne of 2 routes

CHEBI:28862Reach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
dGMP + inosine = 2'-deoxyguanosine + IMP
ATP:dGMP phosphotransferase

Catalysed by NT5C2, GUK1cytosolOne of 2 routes

L-aspartateReach from here →

dIMP + inosine = 2'-deoxyinosine + IMP
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

Catalysed by NT5C2, ADSS2, ADSS1

D-ribose 1-phosphateReach from here →

5', 3'-nucleotidase (dIMP)
dIMP + inosine = 2'-deoxyinosine + IMP
inosine:phosphate alpha-D-ribosyltransferase

Catalysed by NT5C, NT5C2, PNPcytosol

alpha-D-ribose 1-phosphateReach from here →

5', 3'-nucleotidase (dIMP)
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine

Catalysed by NT5C, NT5C2, PNP, LACC1cytosol

(2R)-3-phosphoglycerateReach from here →

5', 3'-nucleotidase (dIMP)
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

Catalysed by NT5C, PNP, PGM2L1cytosol

2-deoxy-D-ribose 5-phosphateReach from here →

5', 3'-nucleotidase (dIMP)
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

Catalysed by NT5C, PNP, PGM2cytosol