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Proteins/UNIPROT:Q9NRD8
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation. May have its own peroxidase activity through its N-terminal peroxidase-like domain..
Function from UniProtKB (Q9NRD8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
21 statements
21 statements · 6 reference databases · Subject: DUOX2 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
4 reactions
proton+NADPH(4-)+dioxygenhydrogen peroxide+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.11.1.-, 1.6.3.1cytosol
Human-GEM MAR07701CC BY 4.0Reference data
NADPH(4-)+dioxygen+hydronhydrogen peroxide+NADP(3-)
Catalysed by
9 names
Resolves to: DUOX2
Reaction pageLeft to rightBalanced
Rhea RHEA:11260CC BY 4.0Reference data
NADH(2-)+dioxygen+hydronhydrogen peroxide+NAD(1-)
Catalysed by PYROXD1 or DUOX2 or DUOX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:11264CC BY 4.0Reference data
NAADPH+dioxygen+hydronNAADP(+)+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:86235CC BY 4.0Reference data