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Proteins/UNIPROT:Q9NWW6
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine..
Function from UniProtKB (Q9NWW6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
44 statements
44 statements · 6 reference databases · Subject: NMRK1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
ATP+beta-D-ribosylnicotinateADP+proton+nicotinic acid D-ribonucleotide
Reaction pageLeft to rightBalancedEC 2.7.1.173cytosol
Human-GEM MAR04253CC BY 4.0Reference data
ATP+beta-nicotinamide D-ribosideADP+proton+NMN zwitterion
Catalysed by
8 names
Resolves to: NMRK1
Reaction pageLeft to rightBalancedEC 2.7.1.22cytosol
Human-GEM MAR04265CC BY 4.0Reference data
beta-nicotinamide D-riboside+ATP(4-)NMN zwitterion+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:14017CC BY 4.0Reference data
beta-D-ribosylnicotinate+ATP(4-)nicotinate beta-D-ribonucleotide+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:25568CC BY 4.0Reference data