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Proteins/UNIPROT:Q9NZJ9
Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates. Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate. Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity)..
Function from UniProtKB (Q9NZJ9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
82 statements
82 statements · 4 reference databases · Subject: NUDT4 · Sources: Bgee, Reactome, Rhea, UniProt
8 reactions
MAM01133c+waterproton+MAM02492c+phosphate(3-)
Catalysed by NUDT10 or NUDT4 or NUDT11 or NUDT3
Reaction pageLeft to rightBalancedEC 3.6.1.52cytosol
Human-GEM MAR07655CC BY 4.0Reference data
MAM01710c+waterproton+MAM02493c+phosphate(3-)
Catalysed by
6 names
Resolves to: NUDT4
Reaction pageLeft to rightBalance undeterminableEC 3.6.1.52cytosol
Human-GEM MAR09552CC BY 4.0Reference data
CHEBI:58628+waterCHEBI:58130+hydrogenphosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:22384CC BY 4.0Reference data
P(1),P(5)-bis(5'-adenosyl) pentaphosphate+waterADP(3-)+ATP(4-)+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:30527CC BY 4.0Reference data
P(1),P(6)-bis(5'-adenosyl) hexaphosphate+water2ATP(4-)+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:32043CC BY 4.0Reference data
CHEBI:140372+waterCHEBI:140374+hydrogenphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:56312CC BY 4.0Reference data
CHEBI:142939+waterCHEBI:57733+hydrogenphosphate+hydron
Catalysed by NUDT4
Reaction pageLeft to rightBalanced
Rhea RHEA:59500CC BY 4.0Reference data
5-phospho-alpha-D-ribose 1-diphosphate+wateralpha-D-ribose 1,5-bisphosphate+hydrogenphosphate+hydron
Catalysed by NUDT4
Reaction pageLeft to rightBalanced
Rhea RHEA:80811CC BY 4.0Reference data