(R)-S-lactoylglutathione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

335 compounds within 3 steps: 5 in 1, 91 in 2, 239 in 3

Two steps

L-ascorbic acidReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
Catalysed by HAGH, CLIC1, GSTO1, GSTO2
glycocholateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. solute carrier organic anion transporter (glycocholate)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes
cholateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. solute carrier organic anion transporter (cholate)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes
hydrogen sulfideReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by HAGH, TSTD1
an alcoholReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Catalysed by HAGH, CP, PRDX6
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of arachidonate and GSH (cytosol to extracellular)
Catalysed by HAGH, HAGHLcytosol, extracellular spaceOne of 2 routes
serotoninReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and serotonin (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
glycochenodeoxycholateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by HAGH, ABCC4inner side of the membrane, outer side of the membrane
taurocholateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. solute carrier organic anion transporter (GSH)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes
glycolithocholic acidReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of glycolithocholate and GSH (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
tert-butanolReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O
Catalysed by HAGH, CLIC2, GPX1, GPX2 and 2 more
gamma-Glu-AlaReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. gamma-glutamyltransferase (alanine)
Catalysed by HAGH, HAGHL, GGT1, GGT5 and 4 morecytosol, extracellular space
3,3',5-triiodo-L-thyronineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and triiodothyronine (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
prostaglandin E1Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin I2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin I2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin F2alphaReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin H2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin D2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by HAGH, HAGHL, GPX5, GPX1 and 7 morecytosolOne of 2 routes
leukotriene A4Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and leukotriene A4 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
S-formylglutathioneReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. alcohol dehydrogenase (formaldehyde)
Catalysed by HAGH, HAGHL, ADH1C, ADH1A and 4 morecytosolOne of 2 routes
leukotriene C4Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. leukotriene C4 synthase (GSH)
Catalysed by HAGH, HAGHL, LTC4ScytosolOne of 5 routes
glutathione disulfideReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. Glutathione: 5-HPETE oxidoreductase
Catalysed by HAGH, HAGHL, GPX5, GPX1 and 7 morecytosolOne of 35 routes
taurolithocholate 3-sulfateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
5-oxo-L-prolineReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
Catalysed by HAGH, CHAC2, CHAC1
histamineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and histamine (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
L-thyroxineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and thyroxine (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
S-sulfanylglutathioneReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. Sulfide:glutathione,quinone oxidoreductase
Catalysed by HAGH, HAGHL, SQORcytosol, mitochondrial matrixOne of 5 routes
dopamineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of dopamine and GSH (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
glycolithocholate 3-sulfateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
prostaglandin E2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
L-cysteinylglycineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. glutathione gamma-glutamylaminopeptidase
Catalysed by HAGH, HAGHL, GGTLC3, GGT1 and 4 morecytosolOne of 6 routes
ubiquinol-10Reach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10
Catalysed by HAGH, SQOR
(R)-noradrenalineReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and noradrenaline (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by HAGH, GPX1, GPX4
ursodeoxycholateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes
glycodeoxycholateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by HAGH, ABCC4inner side of the membrane, outer side of the membrane
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by HAGH, GPX1, GPX2, GPX4
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by HAGH, PTGES, MGST3, GPX1 and 3 more
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by HAGH, GPX1, GPX4
thromboxane B2Reach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by HAGH, HAGHL, SLCO1B1cytosol, extracellular spaceOne of 2 routes
an S-substituted glutathioneReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by HAGH, GSTT4, GSTA4, GSTZ1 and 20 moreOne of 2 routes
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by HAGH, GPX1, GSTA1, GPX2 and 1 more
taurochenodeoxycholateReach from here →
1. (R)-S-Lactoylglutathione hydrolase
2. solute carrier organic anion transporter (GSH)
Catalysed by HAGH, HAGHL, SLCO1A2, SLC7A9 and 1 morecytosol, extracellular spaceOne of 3 routes

Three steps

(S)-carnitineReach from here →
Catalysed by HAGH, HAGHLcytosol, extracellular space, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
Catalysed by HAGH, and 31 more