chlorine(.)

Three steps

• methylarsonous acidReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GSTO1 and 1 moreextracellular space, cytosol

• all-trans-retinalReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosol

• butanoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC26A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• thiocyanateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC26A1 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• 4-fumarylacetoacetateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, FAHextracellular space, cytosolOne of 2 routes

• dTDPReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 4 moreextracellular space, cytosol

• indole-3-acetaldehydeReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. L-tryptophan decarboxy-lyase
  3. Tryptamine:oxygen oxidoreductase(deaminating)

  Catalysed by SLC6A14, DDC, AOC1, MAOA and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:18183Reach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLC6A14, GGT1, GGT5, GGTLC2 and 5 moreextracellular space, cytosolOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosolOne of 2 routes

• arsenic triglutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by SLC6A9, SLC6A14, GSS, AS3MTextracellular space, cytosolOne of 3 routes

• CHEBI:18381Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by SLC26A4, MTHFD1, ATICextracellular space, cytosol

• CHEBI:18405Reach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine 5'-phosphate:oxygen oxidoreductase

  Catalysed by SLC6A14, SCLY, PNPOextracellular space, cytosolOne of 3 routes

• hydrogen cyanideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC26A6, SLC25A14, SLC25A30, MPST and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, AGXT2, GCLCextracellular space, cytosol

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by SLC6A14, SDS, SDSL, BCKDHA and 1 moreextracellular space, cytosol, mitochondrial matrix

• N-methyltryptamineReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. L-tryptophan decarboxy-lyase
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLC6A14, DDC, INMTextracellular space, cytosol

• D-isoleucineReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by SLC6A14, SLC1A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC6A9, SLC6A14, GSS, MGST3extracellular space, cytosol

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Xaa-L-Pro dipeptideReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by SLC6A14, SLC1A4, PEPDextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (6R)-10-formyltetrahydrofolateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by SLC6A9, SLC6A14, SHMT1, SHMT2 and 2 moreextracellular space, cytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GPX1 and 1 moreextracellular space, cytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GPX1 and 1 moreextracellular space, cytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GPX1 and 1 moreextracellular space, cytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GPX1 and 1 moreextracellular space, cytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, GPX4extracellular space, cytosol

• biocytinReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC6A14, SLC7A9, SLC25A29, SLC7A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• glycodeoxycholate 3-sulfateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, SULT2A1extracellular space, cytosol

• taurodeoxycholate 3-sulfateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurodeoxycholate + 3'-phosphoadenylyl sulfate = taurodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC6A6, BAAT, SULT2A1extracellular space, cytosol

• 3',5'-diiodo-L-thyronineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by SLC6A6, MTO1, DIO3extracellular space, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC6A9, SLC6A14, AADAT, AGXT2extracellular space, cytosolOne of 9 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC6A9, SLC6A14, AADAT, AGXT2extracellular space, cytosolOne of 4 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC6A9, SLC6A14, AADAT, AGXT2extracellular space, cytosolOne of 4 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Carnitine Transport by Atb0
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC6A14, SLC33A1, ESCO2, OXSM and 2 moreextracellular space, cytosol, mitochondrial matrix

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 7 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. transport of betaine and chloride (cytosol to extracellular)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by SLC6A12, SLC22A5, CRATextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC6A6, BAAT, HADHA, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLC6A14, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• 3-iodothyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by SLC6A6, MTO1, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by SLC6A6, MTO1, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• serotonin O-sulfateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC6A4, SULT1A3 and 1 moreextracellular space, cytosol

• L-thyronineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by SLC6A6, MTO1, DIO3extracellular space, cytosol

• thyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO3extracellular space, cytosol

• 3'-iodothyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO3extracellular space, cytosol