S-methylmercury-L-cysteine

Three steps

• Gly-tRNA(Gly)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, GARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, WARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of isoleucine and methionine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, IARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, QARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• isocyanateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of citrulline and methionine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC7A8, SLC7A6, LACC1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of asparagine and methionine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, NARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• hydrogenselenideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by SLC7A8, CDKAL1, SCLYinner side of the membrane, outer side of the membrane

• glycocholateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A8, SLC7A5, CTHinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:30249Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A8, SLC7A5, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• formic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC26A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by SLC7A8, SLC43A1, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• malonic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by SLC7A8, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC7A8, PM20D1inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC7A8, PM20D1inner side of the membrane, outer side of the membrane

• D-lysineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• putrescineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of arginine and methionine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC7A8, SLC7A6, SLC3A2, SLC7A7inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC7A8, SLC7A13, CADinner side of the membrane, outer side of the membrane

• di-mu-sulfido-diiron(2+)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC7A8, SLC7A5, NDUFAB1, FDXR and 5 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of isoleucine and methionine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A8, SLC7A5, BCAT2, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-cysteineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-serineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes

• 5-aminolevulinateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC7A8, SLC7A5, ALAS1, ALAS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of isoleucine and methionine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, GOT2, GOT1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• glycochenodeoxycholateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycochenodeoxycholic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC7A8, SLC7A5, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 14 routes

• 3-hydroxyisovaleric acidReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. 4-methyl-2-oxopentanoate decarboxylation

  Catalysed by SLC7A8, BCAT2, ALOX12B, ALOXE3inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• glycolithocholic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC7A8, SLC7A5, GCATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• 25-hydroxycholesterolReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by SLC7A8, CDKAL1, CH25Hinner side of the membrane, outer side of the membrane

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC7A8, PAH, PCBD1, PCBD2inner side of the membrane, outer side of the membrane

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

  Catalysed by SLC7A8, AADAT, ADI1inner side of the membrane, outer side of the membrane

• gamma-Glu-AlaReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC7A8, SLC7A5, GGT1, GGT5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC7A8, SLC7A5, GLDC, GCSHinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC7A8, NAGS, BAATinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by SLC7A8, CDKAL1, RETSATinner side of the membrane, outer side of the membrane

• 3,3',5-triiodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO2inner side of the membrane, outer side of the membrane

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO3inner side of the membrane, outer side of the membrane

• (R)-methylmalonyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC7A8, NAGS, ALDH6A1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC7A8, NAGSinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC7A8, NAGS, ACP2inner side of the membrane, outer side of the membrane, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC7A8, NAGSinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC7A8, NAGS, ACAA1, MYO5Binner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC7A8, NAGS, ACSM4, ACSM1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes