N-carbamoyl-beta-alanine

Three steps

• 2-aminoisobutanoateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by UPB1, AGXT2, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by UPB1, AGXT2cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC6A14, CARS2extracellular space, cytosol

• alpha-linolenic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC6A9, SLC6A14, GLYATextracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC6A14, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by UPB1, AGXT2, SCLYcytosol

• N-acetyl-L-cysteineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A35, SLC25A34extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by UPB1, GADL1, CSAD, SLC1A7 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Ca(2+)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC24A1, SLC24A5 and 3 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC6A14, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC6A14, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC6A9, SLC6A14, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by UPB1, GADL1, CSAD, DARS1cytosol

• Trp-tRNA(Trp)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC6A14, QARS1extracellular space, cytosol

• hypoioditeReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC26A4, MPO, LPOextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC6A14, NARS1extracellular space, cytosol

• phosphocholineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC6A9, SLC6A14, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC6A14, CTHextracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1extracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC6A14, IDO1, TDO2, IDO2extracellular space, cytosol

• oxalateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC26A2, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• propionic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• butyric acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• isocitric acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (2R,3R)-tartrateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• L-lysineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)

  Catalysed by UPB1, GATM, SLC25A2, SLC25A15cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by UPB1, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-ornithine carboxy-lyase (putrescine-forming)

  Catalysed by UPB1, GATM, ODC1cytosolOne of 4 routes

• D-arginineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by UPB1, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• N-carbamoyl-L-aspartateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by UPB1, GADL1, CSAD, CADcytosol

• thiosulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC26A1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC6A14, IL4I1extracellular space, cytosol