indole-3-pyruvate

Three steps

• enol-oxaloacetateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by AADAT, CLYBL, SDHB, SDHA

• AH2Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AADAT, SLC7A5, MOCOSextracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AADAT, SLC7A5, ALAS1, ALAS2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by AADAT, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by AADAT, SLC7A6, HALextracellular space, cytosol

• urateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:17927Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by AADAT, SLC7A6, SLC3A2extracellular space, cytosol

• fumaric acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by AADAT, CLYBL, FHcytosolOne of 5 routes

• dTDPReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. pyruvate kinase (dTDP)

  Catalysed by AADAT, AGXT, AGXT2, PKM and 1 morecytosol

• indole-3-acetaldehydeReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan decarboxy-lyase
  3. Tryptamine:oxygen oxidoreductase(deaminating)

  Catalysed by AADAT, DDC, AOC1, MAOA and 1 morecytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by AADAT, SLC7A5, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Ureidopropionate

  Catalysed by AADAT, SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AADAT, SLC7A5, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by AADAT, SLC7A5, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by AADAT, SLC7A5, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by AADAT, SLC7A5, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by AADAT, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by AADAT, AGXT2, BCKDHA, BCKDHBmitochondrial matrix

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-methyltryptamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan decarboxy-lyase
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by AADAT, DDC, INMTcytosol

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, SLC7A5, AGXT2extracellular space, cytosolOne of 4 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by AADAT, SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by AADAT, SLC7A5, CARS2extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AADAT, SLC7A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• a quinolReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by AADAT, CLYBL, SDHB, SDHA

• hypochlorous acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Peroxidase

  Catalysed by AADAT, SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of chloride (cytosol to extracellular)

  Catalysed by AADAT, SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by AADAT, SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• selenomethionineReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by AADAT, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by AADAT, AGXT2, CTHcytosol

• (2-hydroxyphenyl)acetic acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AADAT, HPDcytosol

• 2-oxopentanoateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AADAT, AGXT2

• CHEBI:28666Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by AADAT, SLC7A5extracellular space, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AADAT, SLC7A5, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by AADAT, SLC7A5, NAGSextracellular space, cytosol, mitochondrial matrix

• L-ascorbic acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
  3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by AADAT, PAMOne of 6 routes

• K(+)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by AADAT, SLC7A5, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by AADAT, BCKDHA, BCKDHBmitochondrial matrix

• Cys-tRNA(Cys)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of isoleucine and tryptophan (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of citrulline and tryptophan (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by AADAT, SLC7A9, SLC3A1, SLC7A6 and 1 moreextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of asparagine and tryptophan (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, NARS1extracellular space, cytosol