cortisol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

140 compounds within 3 steps: 4 in 1, 26 in 2, 110 in 3

One step

acetaldehydeReach from here →
1. cytochrome P450 (cortisol)
Catalysed by CYP17A1endoplasmic reticulum
cortisoneReach from here →
1. Cortisol:NADP+ 11-oxidoreductase
Catalysed by HSD11B1cytosolOne of 5 routes
11beta-hydroxyandrost-4-ene-3,17-dioneReach from here →
1. steroid 11beta-monooxygenase (cortisol)
Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2cytosolOne of 4 routes
acetateReach from here →
1. steroid 11beta-monooxygenase (cortisol)
Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2cytosolOne of 3 routes

Two steps

2-hydroxybutyric acidReach from here →
1. steroid 11beta-monooxygenase (cortisol)
2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 2 routes
N-acetylcadaverineReach from here →
1. steroid 11beta-monooxygenase (cortisol)
2. N-acetylcadaverine + H2O = cadaverine + acetate
Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 more

Three steps

cytosol

acetoacetateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 5 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 3 morecytosol

acetylpyruvateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

pyruvateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 5 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 3 morecytosol, extracellular spaceOne of 2 routes

CHEBI:16132Reach from here →

Catalysed by CYP17A1, DERAendoplasmic reticulum, cytosol

N(2)-acetyl-L-ornithineReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 2 routes

17alpha-hydroxyprogesteroneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2cytosol, endoplasmic reticulum

4-methylumbelliferyl acetateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 3 morecytosol

androst-4-ene-3,11,17-trioneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosolOne of 2 routes

17alpha-hydroxypregnenoloneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2cytosol, endoplasmic reticulum

formic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 3 morecytosol, extracellular spaceOne of 2 routes

propionic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 2 routes

N-(acetyl)-sphing-4-enineReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

N-acetyl-D-glucosamine 6-phosphateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

phosphoethanolamineReach from here →

Catalysed by CYP17A1, ETNPPLendoplasmic reticulum

N-acetylputrescineReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

N(8)-acetylspermidineReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

an N-acetyl-L-cysteine-S-conjugateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

2-deoxy-D-ribose 5-phosphateReach from here →

Catalysed by CYP17A1, DERAendoplasmic reticulum

11beta,17beta-dihydroxyandrost-4-ene-3-oneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 more

cytosol, extracellular space

One of 2 routes

prostaglandin A2Reach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 3 routes

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 28 morecytosol, extracellular spaceOne of 2 routes

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 2 morecytosol

2-nonadioyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 2 morecytosol

CHEBI:15345Reach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 3 routes

acetoneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 5 morecytosol, extracellular space, mitochondrial matrix

propionyl-CoAReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 7 morecytosol, extracellular spaceOne of 3 routes

(S)-malateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 4 morecytosol, extracellular spaceOne of 2 routes

alpha-D-glucosamine 6-phosphateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 2 morecytosol

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular space, mitochondrial matrix

(17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 1 morecytosol, endoplasmic reticulumOne of 2 routes

androst-4-ene-3,17-dioneReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2cytosol, endoplasmic reticulumOne of 5 routes

oxaloacetateReach from here →

Catalysed by CYP17A1, CYP11B1, CYP11B2, BCO2 and 6 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes