20alpha-hydroxy-5alpha-pregnane-3-one
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
12 compounds within 3 steps: 1 in 1, 2 in 2, 9 in 3
One step
Catalysed by AKR1C3cytosol
Two steps
- 5alpha-pregnan-20alpha-ol-3-one:NADP+ 20-oxidoreductase
- 3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
Catalysed by AKR1C3, AKR1C4, AKR1C2, AKR1C1cytosolOne of 3 routes
Three steps
- 5alpha-pregnan-20alpha-ol-3-one:NADP+ 20-oxidoreductase
- 5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase
- progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by AKR1C3, SRD5A1, SRD5A2, SRD5A3 and 2 morecytosol