What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Statements
3 statements
3 statements · 1 reference database · Subject: (20R)-20-hydroxypregn-4-en-3-one · Sources: Human-GEM
- (20R)-20-hydroxypregn-4-en-3-one is converted to progesteroneCompoundHuman-GEM MAR10066Inferred only
- progesterone is converted to (20R)-20-hydroxypregn-4-en-3-oneCompoundHuman-GEM MAR07976Inferred only
- (20R)-20-hydroxypregn-4-en-3-one is a substrate of AKR1C1ProteinHuman-GEM MAR10066Inferred only
Reactions
7 reactions
proton+NADPH(4-)+progesterone(20R)-20-hydroxypregn-4-en-3-one+NADP(3-)
Catalysed by AKR1C1
Reaction pageLeft to rightBalancedEC 1.1.1.149GO:0005829
Human-GEM MAR07976CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one(20R)-20-hydroxypregn-4-en-3-one
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR07977CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09268CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one+NAD(+)proton+NADH(2-)+progesterone
Catalysed by AKR1C1
Reaction pageLeft to rightBalancedEC 1.1.1.149GO:0005829
Human-GEM MAR10066CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one+ATP+water+sodium(1+)(20R)-20-hydroxypregn-4-en-3-one+ADP+proton+sodium(1+)+phosphate(3-)
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR11573CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one+water(20R)-20-hydroxypregn-4-en-3-one+water
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR11647CC BY 4.0Reference data
(20R)-20-hydroxypregn-4-en-3-one+NAD(1-)progesterone+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:46016CC BY 4.0Reference data