sn-glycerol 3-phosphocholine

Three steps

• 13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine (cytosol to extracellular)

  Catalysed by GPCPD1, CHAT, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS1, PTGS2cytosol

• 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS2cytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT4 and 2 more

• beta-D-fructose 1-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate

  Catalysed by GDPD5, GPCPD1, GPD1, GPD1L and 1 moreOne of 2 routes

• (7Z)-octadecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, AACScytosolOne of 2 routes

• CHEBI:15380Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GPCPD1, CHAT, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GPCPD1, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1BcytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GPCPD1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GPCPD1, CHAT, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GPCPD1, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by GPCPD1, CHAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by GPCPD1, CHATcytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, ACSS3, ACSS2 and 1 morecytosolOne of 43 routes

• L-leucineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GPCPD1, CHAT, ZDHHC11B, NAA10 and 30 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GPCPD1, CHAT, NAA10cytosol

• CHEBI:15746Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GPCPD1, CHAT, SAT1, SAT2cytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by GPCPD1, GPD2, GNPATcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15971Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular space

• dihydroxyacetoneReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. Alkaline Phosphatase

  Catalysed by GPCPD1, GPD2, ALPL, ALPP and 2 morecytosol, mitochondrial matrixOne of 3 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. sn-Glycero-3-phosphocholine cholinephosphohydrolase
  2. CTP:choline-phosphate cytidylyltransferase
  3. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CHPT1 and 1 morecytosol

• sulfateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC26A6cytosol, extracellular space

• 11-cis-retinolReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GPCPD1, CHAT, DGAT1, LRAT and 3 morecytosol

• cob(II)alaminReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by GPCPD1, CHDH, MTRRcytosol

• phosphatidic acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 10 morecytosol, mitochondrial matrixOne of 8 routes

• iodideReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC26A4cytosol, extracellular spaceOne of 23 routes

• L-valineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• oxaloacetateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by GPCPD1, CHAT, ACLYcytosol

• L-arginineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• nitric oxideReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by GPCPD1, CHDH, SUOXcytosol

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by GPCPD1, CHDH, RSAD2cytosol

• (S)-2-hydroxyglutarateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by GPCPD1, CHDH, L2HGDHcytosol

• CHEBI:16856Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by GPCPD1, CHAT, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular space

• oxalic acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC26A6cytosol, extracellular space

• methylglyoxalReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)

  Catalysed by GPCPD1, GPD2cytosol, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by GPCPD1, SLC5A7, CLTRN, SLC6A20cytosol, extracellular spaceOne of 2 routes