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9-hydroxy-(10E,12Z)-octadecadienoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

9 compounds within 3 steps: 1 in 1, 2 in 2, 6 in 3

Does it reach a compound?

One step

(9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
1. prostaglandin-endoperoxide synthase (9(S)-HPODE)
Catalysed by PTGS1, PTGS2cytosol

Two steps

glutathione disulfideReach from here →
1. prostaglandin-endoperoxide synthase (9(S)-HPODE)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by PTGS1, PTGS2, GPX1, GPX4cytosol
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. prostaglandin-endoperoxide synthase (9(S)-HPODE)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by PTGS1, PTGS2, GPX1, GPX4cytosol

Three steps

15(S)-HPETEReach from here →
Catalysed by PTGS1, PTGS2, GPX1, GPX4 and 7 morecytosol
L-cystineReach from here →

Catalysed by PTGS1, PTGS2, GPX1, GPX4

cytosol

CHEBI:16856Reach from here →

prostaglandin-endoperoxide synthase (9(S)-HPODE)
(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Glutathione: 15-HPETE oxidoreductase

Catalysed by PTGS1, PTGS2, GPX1, GPX4 and 7 morecytosolOne of 7 routes

methylarsonateReach from here →

prostaglandin-endoperoxide synthase (9(S)-HPODE)
(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

Catalysed by PTGS1, PTGS2, GPX1, GPX4 and 2 morecytosol

thiosulfateReach from here →

prostaglandin-endoperoxide synthase (9(S)-HPODE)
(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by PTGS1, PTGS2, GPX1, GPX4 and 1 morecytosol

glutathioneReach from here →

prostaglandin-endoperoxide synthase (9(S)-HPODE)
(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

Catalysed by PTGS1, PTGS2, GPX1, GPX4 and 1 morecytosolOne of 4 routes