quinolinic acid

Three steps

• ubiquinonesReach from here →
  1. Transport of Quinolinic Acid
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC22A6, SLC25A10, SDHD, SDHB and 2 moreextracellular space, cytosol, mitochondrial matrix

• L-valineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by SLC22A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 11 routes

• L-arginineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. Transport of Quinolinic Acid
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by SLC22A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• pregnenoloneReach from here →
  1. Transport of Quinolinic Acid
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SLC22A6, STSextracellular space, cytosol, Golgi apparatusOne of 4 routes

• 3-fumarylpyruvateReach from here →
  1. Transport of Quinolinic Acid
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC22A6, SLC25A10, FAHD1extracellular space, cytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. Transport of Quinolinic Acid
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC22A6, SLC25A14, SLC25A30, SUOXextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. Transport of Quinolinic Acid
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC22A6, SLC25A14, SLC25A30, NAT8Lextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC22A6, SLC26A6, CLTRN, SLC6A20extracellular space, cytosolOne of 3 routes

• estroneReach from here →
  1. Transport of Quinolinic Acid
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLC22A6, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. Transport of Quinolinic Acid
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC22A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• enol-oxaloacetateReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC22A6, SLC25A10, SDHB, SDHAextracellular space, cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. Transport of Quinolinic Acid
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SLC22A6, STSextracellular space, cytosol, Golgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A12extracellular space, cytosolOne of 3 routes

• urateReach from here →
  1. Transport of Quinolinic Acid
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC25A35, SLC25A34extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• butanoateReach from here →
  1. Transport of Quinolinic Acid
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC22A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosol

• thiocyanateReach from here →
  1. Transport of Quinolinic Acid
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC22A6, SLC25A14, SLC25A30, SLC26A1 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Transport of Quinolinic Acid
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC22A6, SLC25A10, FAHextracellular space, cytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC22A6, SLC26A6, SLC6A14extracellular space, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, CLTRN, SLC6A20extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC22A6, SLC26A6extracellular space, cytosolOne of 2 routes

• hydrogen cyanideReach from here →
  1. Transport of Quinolinic Acid
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC22A6, SLC25A14, SLC25A30, MPST and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. Transport of Quinolinic Acid
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. Transport of Quinolinic Acid
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:240943Reach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC22A6, SLC26A6, SLC6A5extracellular space, cytosolOne of 2 routes

• a quinolReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC22A6, SLC25A10, SDHB, SDHAextracellular space, cytosol, mitochondrial matrix

• hypochlorous acidReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC22A6, SLC26A6, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. Transport of Quinolinic Acid
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLC22A6, STSextracellular space, cytosolOne of 3 routes

• K(+)Reach from here →
  1. Transport of Quinolinic Acid
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC22A6, SLC25A14, SLC25A30, SLC1A7 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. Transport of Quinolinic Acid
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC22A6, SLC25A14, SLC25A30, DARS1extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. Transport of Quinolinic Acid
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC22A6, SLC25A14, SLC25A30, SLC26A1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. Transport of Quinolinic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC22A6, SLC26A6, SLC26A4extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by SLC22A6, SLC25A10, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 10 routes

• (indol-3-yl)acetateReach from here →
  1. Transport of Quinolinic Acid
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC22A6, SLC25A10, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 6 routes

• glutarateReach from here →
  1. Transport of Quinolinic Acid
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC22A6, STS, SLC22A24, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• pentanoateReach from here →
  1. Transport of Quinolinic Acid
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC22A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• cis-aconitic acidReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC22A6, SLC25A10, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. Transport of Quinolinic Acid
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC22A6, SLC25A14, SLC25A30, CADextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. Transport of Quinolinic Acid
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC22A6, ARSL, ARSF, ARSK and 3 moreextracellular space, cytosol

• D-ribose 1-phosphateReach from here →
  1. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)
  2. nicotinate D-ribonucleotide phosphohydrolase
  3. Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase

  Catalysed by QPRT, ACP3, NT5E, NT5C and 5 morecytosol

• glyoxylateReach from here →
  1. Transport of Quinolinic Acid
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC22A6, SLC25A10, CLYBLextracellular space, cytosol, mitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. Transport of Quinolinic Acid
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes