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Proteins/UNIPROT:Q8TCD5
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP (Ref.12). Also dephosphsphorylates dTMP, exhibits intermediate activity towards dGMP, and low activity towards dCMP and dAMP (By similarity)..
Function from UniProtKB (Q8TCD5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
46 statements
46 statements · 7 reference databases · Subject: NT5C · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
28 reactions
6 names
Resolves to: NT5C
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04010CC BY 4.0Reference data
dTMP+waterphosphate(3-)+thymidine
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B or NT5M
Reaction pageLeft to rightBalancedEC 3.1.3.5, 3.1.3.35cytosol
Human-GEM MAR04056CC BY 4.0Reference data
AMP+wateradenosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B or NT5M
Reaction pageLeft to rightBalancedEC 3.1.3.5extracellular space
Human-GEM MAR04081CC BY 4.0Reference data
water+nicotinic acid D-ribonucleotidebeta-D-ribosylnicotinate+phosphate(3-)
Catalysed by ACP3 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04252CC BY 4.0Reference data
water+NMN zwitterionbeta-nicotinamide D-riboside+phosphate(3-)
Catalysed by ACP3 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04264CC BY 4.0Reference data
water+CHEBI:17202inosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C or NT5E or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04417CC BY 4.0Reference data
GMP+waterguanosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04449CC BY 4.0Reference data
dTMP+waterphosphate(3-)+thymidine
Catalysed by ACP3 or NT5C3A or NT5C or NT5E or NT5C1B or NT5M
Reaction pageLeft to rightBalancedEC 3.1.3.5, 3.1.3.35mitochondrial matrix
Human-GEM MAR04484CC BY 4.0Reference data
dCMP+water2'-deoxycytidine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04510CC BY 4.0Reference data
dGMP+water2'-deoxyguanosine+phosphate(3-)
Catalysed by ACP3 or NT5C2 or NT5C1A or NT5C3A or NT5C or NT5E or NT5C3B or RBAK or NT5C1B
Reaction pageLeft to rightBalancedEC 3.1.3.5cytosol
Human-GEM MAR04602CC BY 4.0Reference data
dUMP+water2'-deoxyuridine+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.-cytosol
Human-GEM MAR04642CC BY 4.0Reference data