oxaloacetate

Two steps

• glyoxylic acidReach from here →
  1. D-aspartate:2-oxoglutarate aminotransferase
  2. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

  Catalysed by GOT2, HOGA1mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by GOT2, NAT8Lmitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by CS, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. Oxaloacetate Decarboxylase
  2. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by FAHD1, AGXTcytosol

• CHEBI:17203Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Aspartate Intake by System Asct-1 Transporter

  Catalysed by GOT2mitochondrial matrix, extracellular space, cytosol

• anilineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CS, NAT2, NAT1mitochondrial matrix, cytosol

• aceneuramateReach from here →
  1. Oxaloacetate Decarboxylase
  2. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by FAHD1, NPLcytosol

• CHEBI:17312Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CSmitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. Oxaloacetate Decarboxylase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by FAHD1, TYW1B, TYW1cytosol

• sulfiteReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SDHB, SDHAmitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CS, NAGSmitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CS, HADHA, ACADVL, HADHBmitochondrial matrix

• CHEBI:17927Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CSmitochondrial matrix, cytosol

• fumaric acidReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by FHmitochondrial matrix, cytosolOne of 5 routes

• L-glutamineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)

  Catalysed by GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• dTDPReach from here →
  1. Oxaloacetate Decarboxylase
  2. pyruvate kinase (dTDP)

  Catalysed by FAHD1, PKM, PKLRcytosol

• dTTPReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. pyruvate kinase (dTDP)

  Catalysed by PCK1, PKM, PKLRcytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by FAHD1, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by FAHD1, AGXT2cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CS, HADHA, ACAA2, HADHBmitochondrial matrixOne of 2 routes

• N-acetylneuraminate 9-phosphateReach from here →
  1. GTP:oxaloacetate carboxy-lyase (adding GTP
  2. N-acetylneuraminate synthase

  Catalysed by PCK1, NANScytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by CS, HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by CS, HADHA, ACADVL, HADHBmitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by CS, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by CS, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• a quinolReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SDHB, SDHAmitochondrial matrix, cytosol

• potassium atomReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of aspartate (cytosol to extracellular)

  Catalysed by GOT2, SLC1A7, SLC1A3, SLC1A2 and 2 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:27540Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• 2-oxopentanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  2. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AGXT2

• CHEBI:28701Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CS, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes

• K(+)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GOT2, SLC1A7, SLC1A3, SLC1A2 and 2 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• Asp-tRNA(Asp)Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by GOT2, DARS1mitochondrial matrix, cytosol

• acetateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 2 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. maleate(in) + citrate(out) = maleate(out) + citrate(in)

  Catalysed by CS, SLC25A1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. Oxaloacetate Decarboxylase
  2. L-Serine:pyruvate aminotransferase

  Catalysed by FAHD1, AGXTcytosolOne of 2 routes

• isocitric acidReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A1mitochondrial matrix, cytosolOne of 8 routes

• cis-aconitic acidReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A1mitochondrial matrix, cytosolOne of 8 routes

• N-carbamoyl-L-aspartateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by GOT2, CADmitochondrial matrix

• 3-oxopropanoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by FAHD1, AGXT2cytosol

• thiosulfateReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. transport of malate and thiosulfate (cytosol to mitochondria)

  Catalysed by SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• 2-oxohexanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  2. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by AGXT2

• D-serineReach from here →
  1. Oxaloacetate Decarboxylase
  2. D-serine = pyruvate + NH4(+)

  Catalysed by FAHD1, SRRcytosol