L-homoarginine

Three steps

• 3-methyl-2-oxobutanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and valine (cytosol to extracellular)
  3. L-Valine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• AReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycoursodeoxycholateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• epsilon-(gamma-L-glutamyl)-L-lysineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

  Catalysed by SLC25A2, SLC25A15, GGACTinner side of the membrane, outer side of the membrane

• N-(9Z-octadecenoyl)glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL3, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC25A2, SLC7A6, PM20D1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC25A2, SLC7A6, PM20D1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC25A2, SLC7A6, PM20D1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-hexadecanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL3inner side of the membrane, outer side of the membrane, cytosol

• N-dodecanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-decanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-octanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• L-homocarnosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC25A2, SLC7A5, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol

• L-cystine-bis-glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC25A2, GATM, DPEP1, DPEP2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC25A2, GATM, DPEP1inner side of the membrane, outer side of the membrane, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A2, SLC7A6, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• kinetensinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by SLC25A2, SLC7A6, CMA1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• acetaldehydeReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• cholineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC5A7inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• pyruvateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 18 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 5 routes

• CHEBI:15611Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC25A2, GATM, GNMTinner side of the membrane, outer side of the membrane, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, DHPSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, THinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC25A2, SLC7A6, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• sulfateReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• nitriteReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  3. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)

  Catalysed by SLC25A29, NOS3, NOS1, NOS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC25A2, SLC7A6, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:16523Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 4 routes

• 2-phenylacetamideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC25A2, SLC7A6, EPXinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A2, SLC7A6, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, MARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• cyanamideReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-Arginine amidinohydrolase
  3. urea = cyanamide + H2O

  Catalysed by SLC25A29, ARG1, CA1, CA2inner side of the membrane, outer side of the membrane, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A2, SLC7A6, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC25A2, SLC7A6, CNDP2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC25A2, SLC7A6, SDS, SDSLinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• tryptamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC25A2, SLC7A6, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, KYAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:16856Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, GATM, DAOinner side of the membrane, outer side of the membrane, cytosol, peroxisome

• creatineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by SLC25A29, GATM, GAMTinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes