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Proteins/UNIPROT:Q01970
Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). In conjunction with OSBPL2, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle..
Function from UniProtKB (Q01970), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
496 statements
496 statements · 8 reference databases · Subject: PLCB3 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
6 reactions
water+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycerol+proton+1D-myo-inositol 1-phosphate
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
3 names
Resolves to: PLCB3
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR00663CC BY 4.0Reference data
water+MAM02736ca 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR06559CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCB3 or PLCD3 or PLCB1 or PLCD1 or PLCG2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11nucleus
Human-GEM MAR08818CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycerol+MAM00526c+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR08822CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+water1D-myo-inositol 1,4,5-trisphosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCH2 or PLCG2 or PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCB4 or PLCH1 or PLCZ1 or PLCD3 or PLCD4 or PLCB1 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33179CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+water1D-myo-inositol 1-phosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCXD2 or PLCB4 or PLCD4 or PLCB1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43484CC BY 4.0Reference data